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Journal of Virology, July 2001, p. 6242-6244, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6242-6244.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Interleukin-1 Receptor Antagonist Gene Polymorphism and Circulating Levels of Human Immunodeficiency Virus Type 1 RNA in Brazilian Women

Steven S. Witkin,1,* Iara M. Linhares,2 Stefan Gerber,1 Marie E. Caetano,2 and Alusio C. Segurado2

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York,1 and AIDS Clinic, Departments of Infectious Diseases and Gynecology and Obstetrics, University of Sao Paulo, Sao Paulo, Brazil2

Received 18 December 2000/Accepted 4 April 2001

Interleukin-1 receptor antagonist (IL-1ra) gene polymorphisms in 83 human immunodeficiency virus (HIV)-seropositive women were evaluated. Fourteen of the subjects (16.9%) were homozygous for IL-1ra allele 2 (IL-1RN*2). These women had a lower median level of HIV RNA than did women homozygous for allele 1 (IL-1RN*1) (P = 0.01) or heterozygous for both alleles (P = 0.04). Among 46 subjects not receiving antiretroviral treatment, HIV levels were also reduced in IL-1RN*2 homozygous individuals (P < 0.05). There was no relation between IL-1ra alleles and CD4 levels.

* Corresponding author. Mailing address: Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 515 E. 71st St., New York, NY 10021. Phone: (212) 746-3165. Fax: (212) 746-8799. E-mail: switkin{at}mail.med.cornell.edu.

Journal of Virology, July 2001, p. 6242-6244, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6242-6244.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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