This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wensing, B.
Right arrow Articles by Farrell, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wensing, B.
Right arrow Articles by Farrell, P. J.

 Previous Article  |  Next Article 

Journal of Virology, July 2001, p. 6235-6241, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6235-6241.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Variant Chromatin Structure of the oriP Region of Epstein-Barr Virus and Regulation of EBER1 Expression by Upstream Sequences and oriP

Barbara Wensing,1 Albert Stühler,1,dagger Peter Jenkins,1,Dagger Martine Hollyoake,1,§ Claudio Elgueta Karstegl,1 and Paul J. Farrell1,2,*

Ludwig Institute for Cancer Research1 and Virology and Cell Biology Section,2 Imperial College School of Medicine, London W2 1PG, United Kingdom

Received 19 October 2000/Accepted 3 April 2001

Most of the Epstein-Barr virus genome in latently infected cells is in a standard nucleosomal structure, but the region encompassing oriP and the Epstein-Barr virus-encoded small RNA (EBER) genes shows a distinctive pattern when digested with micrococcal nuclease. This pattern corresponds to a previously mapped nuclear matrix attachment region. Although the EBER genes are adjacent to oriP, there is only a two- to fourfold effect of oriP on EBER expression. However, sequences containing a consensus ATF site upstream of EBER1 are important for EBER1 expression.

* Corresponding author. Mailing address: Ludwig Institute for Cancer Research, Imperial College School of Medicine, Norfolk Place, London W2 1PG, United Kingdom. Phone: 44 20 7563 7703. Fax: 44 20 7724 8586. E-mail: p.farrell{at}ic.ac.uk.

dagger Present address: Department of Internal Medicine, University of Cologne, Cologne D-50931, Germany.

Dagger Present address: Department of Oncology, Cheltenham Hospital, Cheltenham, United Kingdom.

§ Present address: MRC HGMP Resource Centre, Hinxton CB10 1SB, United Kingdom.

Journal of Virology, July 2001, p. 6235-6241, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6235-6241.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Day, L., Chau, C. M., Nebozhyn, M., Rennekamp, A. J., Showe, M., Lieberman, P. M. (2007). Chromatin Profiling of Epstein-Barr Virus Latency Control Region. J. Virol. 81: 6389-6401 [Abstract] [Full Text]  
  • Felton-Edkins, Z. A., Kondrashov, A., Karali, D., Fairley, J. A., Dawson, C. W., Arrand, J. R., Young, L. S., White, R. J. (2006). Epstein-Barr Virus Induces Cellular Transcription Factors to Allow Active Expression of EBER Genes by RNA Polymerase III. J. Biol. Chem. 281: 33871-33880 [Abstract] [Full Text]  
  • Chau, C. M., Lieberman, P. M. (2004). Dynamic Chromatin Boundaries Delineate a Latency Control Region of Epstein-Barr Virus. J. Virol. 78: 12308-12319 [Abstract] [Full Text]  
  • de Jesus, O., Smith, P. R., Spender, L. C., Elgueta Karstegl, C., Niller, H. H., Huang, D., Farrell, P. J. (2003). Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV. J. Gen. Virol. 84: 1443-1450 [Abstract] [Full Text]  
  • Deng, Z., Chen, C.-J., Chamberlin, M., Lu, F., Blobel, G. A., Speicher, D., Cirillo, L. A., Zaret, K. S., Lieberman, P. M. (2003). The CBP Bromodomain and Nucleosome Targeting Are Required for Zta-Directed Nucleosome Acetylation and Transcription Activation. Mol. Cell. Biol. 23: 2633-2644 [Abstract] [Full Text]  
  • White, R. E., Wade-Martins, R., James, M. R. (2001). Sequences Adjacent to oriP Improve the Persistence of Epstein-Barr Virus-Based Episomes in B Cells. J. Virol. 75: 11249-11252 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»