This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Polyak, S. J.
Right arrow Articles by Gretch, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Polyak, S. J.
Right arrow Articles by Gretch, D. R.

 Previous Article  |  Next Article 

Journal of Virology, July 2001, p. 6209-6211, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6209-6211.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Elevated Levels of Interleukin-8 in Serum Are Associated with Hepatitis C Virus Infection and Resistance to Interferon Therapy

Stephen J. Polyak,1,* Khalid S. A. Khabar,2 Mohammed Rezeiq,3 and David R. Gretch1

Department of Laboratory Medicine, University of Washington, Seattle, Washington,1 and Departments of Biological and Medical Research2 and Gastroenterology,3 King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia

Received 29 January 2001/Accepted 2 April 2001

Hepatitis C virus (HCV), a major cause of liver disease worldwide, is frequently resistant to the antiviral alpha interferon (IFN). We have recently found that the HCV NS5A protein induces expression of the proinflammatory chemokine IL-8 to partially inhibit the antiviral actions of IFN in vitro. To extend these observations, in the present study we examined the relationship between levels of IL-8 in serum, HCV infection, and biochemical response to IFN therapy. Levels of IL-8 were significantly elevated in 132 HCV-infected patients compared to levels in 32 normal healthy subjects and were also significantly higher in patients who did not respond to IFN therapy than in patients who did respond to therapy. This study suggests that HCV-induced changes in levels of chemokine and cytokine expression may be involved in HCV antiviral resistance, persistence, and pathogenesis.

* Corresponding author. Mailing address: Virology Division, Box 359690, 325 9th Ave., Seattle, WA 98104-2499. Phone: (206) 341-5224. Fax: (206) 341-5203. E-mail: polyak{at}u.washington.edu.

Journal of Virology, July 2001, p. 6209-6211, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.6209-6211.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Mengshol, J A, Golden-Mason, L, Castelblanco, N, Im, K A, Dillon, S M, Wilson, C C, Rosen, H R, for the Virahep-C Study Group, (2009). Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes. Gut 58: 964-973 [Abstract] [Full Text]  
  • Heydtmann, M. (2009). Macrophages in Hepatitis B and Hepatitis C Virus Infections. J. Virol. 83: 2796-2802 [Full Text]  
  • Nasimuzzaman, M., Waris, G., Mikolon, D., Stupack, D. G., Siddiqui, A. (2007). Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1{alpha} and Stimulates the Synthesis of Vascular Endothelial Growth Factor. J. Virol. 81: 10249-10257 [Abstract] [Full Text]  
  • Khabar, K. S. A. (2007). Rapid transit in the immune cells: the role of mRNA turnover regulation. J. Leukoc. Biol. 81: 1335-1344 [Abstract] [Full Text]  
  • Fiorucci, M., Boulant, S., Fournillier, A., Abraham, J. D., Lavergne, J. P., Paranhos-Baccala, G., Inchauspe, G., Bain, C. (2007). Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuries. J. Gen. Virol. 88: 1149-1162 [Abstract] [Full Text]  
  • Dunn, C., Brunetto, M., Reynolds, G., Christophides, T., Kennedy, P. T., Lampertico, P., Das, A., Lopes, A. R., Borrow, P., Williams, K., Humphreys, E., Afford, S., Adams, D. H., Bertoletti, A., Maini, M. K. (2007). Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. JEM 204: 667-680 [Abstract] [Full Text]  
  • Wohnsland, A., Hofmann, W. P., Sarrazin, C. (2007). Viral Determinants of Resistance to Treatment in Patients with Hepatitis C. Clin. Microbiol. Rev. 20: 23-38 [Abstract] [Full Text]  
  • Wagoner, J., Austin, M., Green, J., Imaizumi, T., Casola, A., Brasier, A., Khabar, K. S. A., Wakita, T., Gale, M. Jr., Polyak, S. J. (2007). Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus Infection. J. Virol. 81: 309-318 [Abstract] [Full Text]  
  • Koo, B. C. A., McPoland, P., Wagoner, J. P., Kane, O. J., Lohmann, V., Polyak, S. J. (2006). Relationships between Hepatitis C Virus Replication and CXCL-8 Production In Vitro.. J. Virol. 80: 7885-7893 [Abstract] [Full Text]  
  • Diago, M, Castellano, G, Garcia-Samaniego, J, Perez, C, Fernandez, I, Romero, M, Iacono, O L, Garcia-Monzon, C (2006). Association of pretreatment serum interferon {gamma} inducible protein 10 levels with sustained virological response to peginterferon plus ribavirin therapy in genotype 1 infected patients with chronic hepatitis C. Gut 55: 374-379 [Abstract] [Full Text]  
  • Moorman, J., Saad, M., Kosseifi, S., Krishnaswamy, G. (2005). Hepatitis C Virus and the Lung: Implications for Therapy. Chest 128: 2882-2892 [Abstract] [Full Text]  
  • Butera, D., Marukian, S., Iwamaye, A. E., Hembrador, E., Chambers, T. J., Di Bisceglie, A. M., Charles, E. D., Talal, A. H., Jacobson, I. M., Rice, C. M., Dustin, L. B. (2005). Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C. Blood 106: 1175-1182 [Abstract] [Full Text]  
  • Kalamvoki, M., Mavromara, P. (2004). Calcium-Dependent Calpain Proteases Are Implicated in Processing of the Hepatitis C Virus NS5A Protein. J. Virol. 78: 11865-11878 [Abstract] [Full Text]  
  • Macdonald, A., Harris, M. (2004). Hepatitis C virus NS5A: tales of a promiscuous protein. J. Gen. Virol. 85: 2485-2502 [Abstract] [Full Text]  
  • Romero-Gomez, M, Montes-Cano, M A, Otero-Fernandez, M A, Torres, B, Sanchez-Munoz, D, Aguilar, F, Barroso, N, Gomez-Izquierdo, L, Castellano-Megias, V M, Nunez-Roldan, A, Aguilar-Reina, J, Gonzalez-Escribano, M F (2004). SLC11A1 promoter gene polymorphisms and fibrosis progression in chronic hepatitis C. Gut 53: 446-450 [Abstract] [Full Text]  
  • Radkowski, M., Bednarska, A., Horban, A., Stanczak, J., Wilkinson, J., Adair, D. M., Nowicki, M., Rakela, J., Laskus, T. (2004). Infection of primary human macrophages with hepatitis C virus in vitro: induction of tumour necrosis factor-{alpha} and interleukin 8. J. Gen. Virol. 85: 47-59 [Abstract] [Full Text]  
  • Kalabay, L., Nemesanszky, E., Csepregi, A., Pusztay, M., David, K., Horvath, G., Ibranyi, E., Telegdy, L., Par, A., Biro, A., Fekete, B., Gervain, J., Horanyi, M., Ribiczey, P., Csondes, M., Kleiber, M., Walentin, S., Prohaszka, Z., Fust, G. (2004). Paradoxical alteration of acute-phase protein levels in patients with chronic hepatitis C treated with IFN-{alpha}2b. Int Immunol 16: 51-54 [Abstract] [Full Text]  
  • Mukaida, N. (2003). Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am. J. Physiol. Lung Cell. Mol. Physiol. 284: L566-L577 [Abstract] [Full Text]  
  • Ni, J., Hembrador, E., Di Bisceglie, A. M., Jacobson, I. M., Talal, A. H., Butera, D., Rice, C. M., Chambers, T. J., Dustin, L. B. (2003). Accumulation of B Lymphocytes with a Naive, Resting Phenotype in a Subset of Hepatitis C Patients. J. Immunol. 170: 3429-3439 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»