Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer

doi:10.1128/JVI.75.13.6199-6203.2001

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Journal of Virology, July 2001, p. 6199-6203, Vol. 75, No. 13
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.13.6199-6203.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer

Markus Hildinger, Alberto Auricchio, Guangping Gao, Lili Wang, Narendra Chirmule, and James M. Wilson^*

Institute for Human Gene Therapy, Departments of Medicine and Molecular and Cellular Engineering, University of Pennsylvania, and The Wistar Institute, Philadelphia, Pennsylvania 19104

Received 7 February 2001/Accepted 6 April 2001

Vectors based on hybrids consisting of adeno-associated virus types 2 (ITRs and Rep) and 5 (Cap) were evaluated for muscle-directedgene transfer (called AAV2/5). Evaluation in immune-competentmice revealed greater transduction efficacy with AAV2/5 than withAAV2 and no cross-neutralization between AAV2/5 and AAV2. Interestingly,we saw no immunologic evidence of previous exposure to AAV5 capsidsin a large population of healthy humansubjects.

^* Corresponding author. Mailing address: 204 The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104-4268. Phone: (215)898-3000. Fax: (215) 898-6588. E-mail: wilsonjm{at}mail.med.upenn.edu.

Journal of Virology, July 2001, p. 6199-6203, Vol. 75, No. 13
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.13.6199-6203.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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