This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McNally, J. M.
Right arrow Articles by Welsh, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McNally, J. M.
Right arrow Articles by Welsh, R. M.

 Previous Article  |  Next Article 

Journal of Virology, July 2001, p. 5965-5976, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.5965-5976.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

James M. McNally, Christopher C. Zarozinski, Meei-Yun Lin, Michael A. Brehm, Hong D. Chen, and Raymond M. Welsh*

Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655

Received 21 November 2000/Accepted 2 April 2001

Experiments designed to distinguish virus-specific from non-virus-specific T cells showed that bystander T cells underwent apoptosis and substantial attrition in the wake of a strong T-cell response. Memory CD8 T cells (CD8+ CD44hi) were most affected. During acute viral infection, transgenic T cells that were clearly defined as non-virus specific decreased in number and showed an increase in apoptosis. Also, use of lymphocytic choriomeningitis virus (LCMV) carrier mice, which lack LCMV-specific T cells, showed a significant decline in non-virus-specific memory CD8 T cells that correlated to an increase in apoptosis in response to the proliferation of adoptively transferred virus-specific T cells. Attrition of T cells early during infection correlated with the alpha/beta interferon (IFN-alpha /beta ) peak, and the IFN inducer poly(I:C) caused apoptosis and attrition of CD8+ CD44hi T cells in normal mice but not in IFN-alpha /beta receptor-deficient mice. Apoptotic attrition of bystander T cells may make room for the antigen-specific expansion of T cells during infection and may, in part, account for the loss of T-cell memory that occurs when the host undergoes subsequent infections.

* Corresponding author. Mailing address: Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave. N., Worcester, MA 01655. Phone: (508) 856-5819. Fax: (508) 856-5780. E-mail: raymond.welsh{at}umassmed.edu.

Journal of Virology, July 2001, p. 5965-5976, Vol. 75, No. 13
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.13.5965-5976.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Huster, K. M., Stemberger, C., Gasteiger, G., Kastenmuller, W., Drexler, I., Busch, D. H. (2009). Cutting Edge: Memory CD8 T Cell Compartment Grows in Size with Immunological Experience but Nevertheless Can Lose Function. J. Immunol. 183: 6898-6902 [Abstract] [Full Text]  
  • Baize, S., Marianneau, P., Loth, P., Reynard, S., Journeaux, A., Chevallier, M., Tordo, N., Deubel, V., Contamin, H. (2009). Early and Strong Immune Responses Are Associated with Control of Viral Replication and Recovery in Lassa Virus-Infected Cynomolgus Monkeys. J. Virol. 83: 5890-5903 [Abstract] [Full Text]  
  • Leitao, C., Freitas, A. A., Garcia, S. (2009). The Role of TCR Specificity and Clonal Competition During Reconstruction of the Peripheral T Cell Pool. J. Immunol. 182: 5232-5239 [Abstract] [Full Text]  
  • Bangs, S. C., Baban, D., Cattan, H. J., Li, C. K.-F., McMichael, A. J., Xu, X.-N. (2009). Human CD4+ Memory T Cells Are Preferential Targets for Bystander Activation and Apoptosis. J. Immunol. 182: 1962-1971 [Abstract] [Full Text]  
  • Choi, H.-J., Xu, H., Geng, Y., Colmone, A., Cho, H., Wang, C.-R. (2008). Bacterial infection alters the kinetics and function of iNKT cell responses. J. Leukoc. Biol. 84: 1462-1471 [Abstract] [Full Text]  
  • Demoulins, T., Abdallah, A., Kettaf, N., Baron, M.-L., Gerarduzzi, C., Gauchat, D., Gratton, S., Sekaly, R.-P. (2008). Reversible Blockade of Thymic Output: An Inherent Part of TLR Ligand-Mediated Immune Response. J. Immunol. 181: 6757-6769 [Abstract] [Full Text]  
  • Wakim, L. M., Gebhardt, T., Heath, W. R., Carbone, F. R. (2008). Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues. J. Immunol. 181: 5837-5841 [Abstract] [Full Text]  
  • Zhang, J.-Y., Zhang, Z., Jin, B., Zhang, S.-Y., Zhou, C.-B., Fu, J.-L., Wang, F.-S. (2008). Cutting Edge: Programmed Death-1 Up-Regulation Is Involved in the Attrition of Cytomegalovirus-Specific CD8+ T Cells in Acute Self-Limited Hepatitis B Virus Infection. J. Immunol. 181: 3741-3744 [Abstract] [Full Text]  
  • Bochtler, P., Kroger, A., Schirmbeck, R., Reimann, J. (2008). Type I IFN-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells. J. Immunol. 181: 1633-1643 [Abstract] [Full Text]  
  • Dudani, R., Murali-Krishna, K., Krishnan, L., Sad, S. (2008). IFN-{gamma} Induces the Erosion of Preexisting CD8 T Cell Memory during Infection with a Heterologous Intracellular Bacterium. J. Immunol. 181: 1700-1709 [Abstract] [Full Text]  
  • Kunz, S., Oberle, K., Sander, A., Bogdan, C., Schleicher, U. (2008). Lymphadenopathy in a Novel Mouse Model of Bartonella-Induced Cat Scratch Disease Results from Lymphocyte Immigration and Proliferation and Is Regulated by Interferon-{alpha}/{beta}. Am. J. Pathol. 172: 1005-1018 [Abstract] [Full Text]  
  • Bradfute, S. B., Warfield, K. L., Bavari, S. (2008). Functional CD8+ T Cell Responses in Lethal Ebola Virus Infection. J. Immunol. 180: 4058-4066 [Abstract] [Full Text]  
  • Blais, M.-E., Brochu, S., Giroux, M., Belanger, M.-P., Dulude, G., Sekaly, R.-P., Perreault, C. (2008). Why T Cells of Thymic Versus Extrathymic Origin Are Functionally Different. J. Immunol. 180: 2299-2312 [Abstract] [Full Text]  
  • Foulds, K. E., Rotte, M. J., Paley, M. A., Singh, B., Douek, D. C., Hill, B. J., O'Shea, J. J., Watford, W. T., Seder, R. A., Wu, C.-Y. (2008). IFN-{gamma} Mediates the Death of Th1 Cells in a Paracrine Manner. J. Immunol. 180: 842-849 [Abstract] [Full Text]  
  • Thornley, T. B., Phillips, N. E., Beaudette-Zlatanova, B. C., Markees, T. G., Bahl, K., Brehm, M. A., Shultz, L. D., Kurt-Jones, E. A., Mordes, J. P., Welsh, R. M., Rossini, A. A., Greiner, D. L. (2007). Type 1 IFN Mediates Cross-Talk between Innate and Adaptive Immunity That Abrogates Transplantation Tolerance. J. Immunol. 179: 6620-6629 [Abstract] [Full Text]  
  • Fang, C., Miwa, T., Shen, H., Song, W.-C. (2007). Complement-Dependent Enhancement of CD8+ T Cell Immunity to Lymphocytic Choriomeningitis Virus Infection in Decay-Accelerating Factor-Deficient Mice. J. Immunol. 179: 3178-3186 [Abstract] [Full Text]  
  • Hogan, L. H., Co, D. O., Karman, J., Heninger, E., Suresh, M., Sandor, M. (2007). Virally Activated CD8 T Cells Home to Mycobacterium bovis BCG-Induced Granulomas but Enhance Antimycobacterial Protection Only in Immunodeficient Mice. Infect. Immun. 75: 1154-1166 [Abstract] [Full Text]  
  • Masopust, D., Murali-Krishna, K., Ahmed, R. (2007). Quantitating the Magnitude of the Lymphocytic Choriomeningitis Virus-Specific CD8 T-Cell Response: It Is Even Bigger than We Thought. J. Virol. 81: 2002-2011 [Abstract] [Full Text]  
  • Hosmalin, A., Lebon, P. (2006). Type I interferon production in HIV-infected patients. J. Leukoc. Biol. 80: 984-993 [Abstract] [Full Text]  
  • Alsharifi, M., Regner, M., Blanden, R., Lobigs, M., Lee, E., Koskinen, A., Mullbacher, A. (2006). Exhaustion of Type I Interferon Response following an Acute Viral Infection.. J. Immunol. 177: 3235-3241 [Abstract] [Full Text]  
  • Aichele, P., Unsoeld, H., Koschella, M., Schweier, O., Kalinke, U., Vucikuja, S. (2006). Cutting edge: CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion.. J. Immunol. 176: 4525-4529 [Abstract] [Full Text]  
  • Bahl, K., Kim, S.-K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F., Selin, L. K., Welsh, R. M. (2006). IFN-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections. J. Immunol. 176: 4284-4295 [Abstract] [Full Text]  
  • Thornley, T. B., Brehm, M. A., Markees, T. G., Shultz, L. D., Mordes, J. P., Welsh, R. M., Rossini, A. A., Greiner, D. L. (2006). TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts. J. Immunol. 176: 1561-1570 [Abstract] [Full Text]  
  • Alsharifi, M., Lobigs, M., Regner, M., Lee, E., Koskinen, A., Mullbacher, A. (2005). Type I Interferons Trigger Systemic, Partial Lymphocyte Activation in Response to Viral Infection. J. Immunol. 175: 4635-4640 [Abstract] [Full Text]  
  • Jiang, J., Gross, D., Nogusa, S., Elbaum, P., Murasko, D. M. (2005). Depletion of T Cells by Type I Interferon: Differences between Young and Aged Mice. J. Immunol. 175: 1820-1826 [Abstract] [Full Text]  
  • Haring, J. S., Corbin, G. A., Harty, J. T. (2005). Dynamic Regulation of IFN-{gamma} Signaling in Antigen-Specific CD8+ T Cells Responding to Infection. J. Immunol. 174: 6791-6802 [Abstract] [Full Text]  
  • Whitmire, J. K., Tan, J. T., Whitton, J. L. (2005). Interferon-{gamma} acts directly on CD8+ T cells to increase their abundance during virus infection. JEM 201: 1053-1059 [Abstract] [Full Text]  
  • Herndon, J. M., Stuart, P. M., Ferguson, T. A. (2005). Peripheral Deletion of Antigen-Specific T Cells Leads to Long-Term Tolerance Mediated by CD8+ Cytotoxic Cells. J. Immunol. 174: 4098-4104 [Abstract] [Full Text]  
  • Kim, S.-K., Cornberg, M., Wang, X. Z., Chen, H. D., Selin, L. K., Welsh, R. M. (2005). Private specificities of CD8 T cell responses control patterns of heterologous immunity. JEM 201: 523-533 [Abstract] [Full Text]  
  • Dikopoulos, N., Bertoletti, A., Kroger, A., Hauser, H., Schirmbeck, R., Reimann, J. (2005). Type I IFN Negatively Regulates CD8+ T Cell Responses through IL-10-Producing CD4+ T Regulatory 1 Cells. J. Immunol. 174: 99-109 [Abstract] [Full Text]  
  • Kemp, R. A., Powell, T. J., Dwyer, D. W., Dutton, R. W. (2004). Cutting Edge: Regulation of CD8+ T Cell Effector Population Size. J. Immunol. 173: 2923-2927 [Abstract] [Full Text]  
  • Doisne, J.-M., Urrutia, A., Lacabaratz-Porret, C., Goujard, C., Meyer, L., Chaix, M.-L., Sinet, M., Venet, A. (2004). CD8+ T Cells Specific for EBV, Cytomegalovirus, and Influenza Virus Are Activated during Primary HIV Infection. J. Immunol. 173: 2410-2418 [Abstract] [Full Text]  
  • Cao, Q., Xia, Y., Azadniv, M., Crispe, I. N. (2004). The E2F-1 Transcription Factor Promotes Caspase-8 and Bid Expression, and Enhances Fas Signaling in T Cells. J. Immunol. 173: 1111-1117 [Abstract] [Full Text]  
  • Peacock, C. D., Welsh, R. M. (2004). Origin and Fate of Lymphocytic Choriomeningitis Virus-Specific CD8+ T Cells Coexpressing the Inhibitory NK Cell Receptor Ly49G2. J. Immunol. 173: 478-484 [Abstract] [Full Text]  
  • Kim, S.-K., Welsh, R. M. (2004). Comprehensive Early and Lasting Loss of Memory CD8 T Cells and Functional Memory during Acute and Persistent Viral Infections. J. Immunol. 172: 3139-3150 [Abstract] [Full Text]  
  • Chapdelaine, Y., Smith, D. K., Pedras-Vasconcelos, J. A., Krishnan, L., Sad, S. (2003). Increased CD8+ T Cell Memory to Concurrent Infection at the Expense of Increased Erosion of Pre-existing Memory: The Paradoxical Role of IL-15. J. Immunol. 171: 5454-5460 [Abstract] [Full Text]  
  • Jiang, J., Lau, L. L., Shen, H. (2003). Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection. J. Immunol. 171: 4352-4358 [Abstract] [Full Text]  
  • Jiang, J., Anaraki, F., Blank, K. J., Murasko, D. M. (2003). Cutting Edge: T Cells from Aged Mice Are Resistant to Depletion Early During Virus Infection. J. Immunol. 171: 3353-3357 [Abstract] [Full Text]  
  • Liu, H., Andreansky, S., Diaz, G., Turner, S. J., Wodarz, D., Doherty, P. C. (2003). Quantitative Analysis of Long-Term Virus-Specific CD8+-T-Cell Memory in Mice Challenged with Unrelated Pathogens. J. Virol. 77: 7756-7763 [Abstract] [Full Text]  
  • Peacock, C. D., Kim, S.-K., Welsh, R. M. (2003). Attrition of Virus-Specific Memory CD8+ T Cells During Reconstitution of Lymphopenic Environments. J. Immunol. 171: 655-663 [Abstract] [Full Text]  
  • Geginat, J., Lanzavecchia, A., Sallusto, F. (2003). Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 101: 4260-4266 [Abstract] [Full Text]  
  • Ely, K. H., Cauley, L. S., Roberts, A. D., Brennan, J. W., Cookenham, T., Woodland, D. L. (2003). Nonspecific Recruitment of Memory CD8+ T Cells to the Lung Airways During Respiratory Virus Infections. J. Immunol. 170: 1423-1429 [Abstract] [Full Text]  
  • Smith, D. K., Dudani, R., Pedras-Vasconcelos, J. A., Chapdelaine, Y., van Faassen, H., Sad, S. (2002). Cross-Reactive Antigen Is Required to Prevent Erosion of Established T Cell Memory and Tumor Immunity: A Heterologous Bacterial Model of Attrition. J. Immunol. 169: 1197-1206 [Abstract] [Full Text]  
  • Drobyski, W. R., Komorowski, R., Logan, B., Gendelman, M. (2002). Role of the Passive Apoptotic Pathway in Graft-Versus-Host Disease. J. Immunol. 169: 1626-1633 [Abstract] [Full Text]  
  • Kim, S.-K., Brehm, M. A., Welsh, R. M., Selin, L. K. (2002). Dynamics of Memory T Cell Proliferation Under Conditions of Heterologous Immunity and Bystander Stimulation. J. Immunol. 169: 90-98 [Abstract] [Full Text]  
  • Murakami, M., Sakamoto, A., Bender, J., Kappler, J., Marrack, P. (2002). CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc. Natl. Acad. Sci. USA 99: 8832-8837 [Abstract] [Full Text]  
  • Holtappels, R., Grzimek, N. K. A., Thomas, D., Reddehase, M. J. (2002). Early gene m18, a novel player in the immune response to murine cytomegalovirus. J. Gen. Virol. 83: 311-316 [Abstract] [Full Text]  
  • Holtappels, R., Thomas, D., Podlech, J., Reddehase, M. J. (2002). Two Antigenic Peptides from Genes m123 and m164 of Murine Cytomegalovirus Quantitatively Dominate CD8 T-Cell Memory in the H-2d Haplotype. J. Virol. 76: 151-164 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»