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Journal of Virology, June 2001, p. 5433-5440, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5433-5440.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Feline Immunodeficiency Virus Cell Entry

Susan C. S. Frey,1 Edward A. Hoover,2 and James I. Mullins1,3,*

Departments of Microbiology1 and Medicine,3 University of Washington, Seattle, Washington, and Department of Pathology, Colorado State University, Fort Collins, Colorado2

Received 3 November 2000/Accepted 14 March 2001

The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.

* Corressponding author. Mailing address: Department of Microbiology, Health Sciences Center, I264, University of Washington, Seattle, WA 98195-7472. Phone: (206) 616-1851. Fax: (360) 838-9259. E-mail: jmullins{at}u.washington.edu.

Journal of Virology, June 2001, p. 5433-5440, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5433-5440.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.