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Journal of Virology, June 2001, p. 5416-5420, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5416-5420.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nasal-Associated Lymphoid Tissue Is a Site of Long-Term Virus-Specific Antibody Production following Respiratory Virus Infection of Mice

Bin Liang, Lisa Hyland, and Sam Hou*

The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom

Received 28 November 2000/Accepted 27 February 2001

Nasal immunoglobulin A provides an initial defense against inhaled respiratory pathogens. However, it is not known whether the nasal-associated lymphoid tissues (NALT) are able to mount an effective long-lasting pathogen-specific immune response, nor is it known whether functional differences exist between the organized NALT (O-NALT) and the diffuse NALT lining the nasal passages (D-NALT). Here we show that although both the O-NALT and the D-NALT are capable of producing virus-specific antibody in response to influenza virus infection, the frequency of specific antibody-forming cells in the D-NALT is much greater than the frequency observed in the O-NALT. Furthermore, we show that the D-NALT but not the O-NALT is the site of long-term virus-specific humoral immunity which lasts for the life of the animal. These results indicate that the D-NALT is not only the major effector site of the NALT but also the site of local long-term specific antibody production.

* Corresponding author. Mailing address: The Edward Jenner Institute, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: 44-1635-577924. Fax: 44-1635-577901. E-mail: sam.hou{at}jenner.ac.uk.

Journal of Virology, June 2001, p. 5416-5420, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5416-5420.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.