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Journal of Virology, June 2001, p. 5410-5415, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5410-5415.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Sequences in Influenza A Virus PB2 Protein That Determine Productive Infection for an Avian Influenza Virus in Mouse and Human Cell Lines

Yongxiu Yao,1 Louise J. Mingay,2 John W. McCauley,3 and Wendy S. Barclay1,*

School of Animal and Microbial Sciences, University of Reading, Reading, Berkshire RG6 6AJ,1 Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE,2 and Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN,3 United Kingdom

Received 23 October 2000/Accepted 20 February 2001

Reverse genetics was used to analyze the host range of two avian influenza viruses which differ in their ability to replicate in mouse and human cells in culture. Engineered viruses carrying sequences encoding amino acids 362 to 581 of PB2 from a host range variant productively infect mouse and human cells.

* Corresponding author. Mailing address: School of Animal and Microbial Sciences, University of Reading, P.O. Box 228, Reading, Berkshire RG6 6AJ, United Kingdom. Phone: 44-1189-316368. Fax: 44-1189-316671. E-mail: w.s.barclay{at}reading.ac.uk.

Journal of Virology, June 2001, p. 5410-5415, Vol. 75, No. 11
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.11.5410-5415.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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