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Journal of Virology, May 2001, p. 4941-4946, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4941-4946.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Patient-Specific Cytotoxic T-Lymphocyte Cross-Recognition of Naturally Occurring Variants of a Human Immunodeficiency Virus Type 1 (HIV-1) p24gag Epitope by HIV-1-Infected Children

F. Buseyne,1,* M.-L. Chaix,2 C. Rouzioux,2 S. Blanche,3 and Y. Rivière1

Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur,1 and Laboratoire de Virologie,2 and Fédération de Pédiatrie,3 Hôpital Necker-Enfants Malades, 75015 Paris, France

Received 29 December 2000/Accepted 27 February 2001

We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24gag QASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.

* Corresponding author. Mailing address: Laboratoire d'Immunopathologie Virale, Département SIDA et Rétrovirus, Institut Pasteur, 28 rue du Dr. Roux, 75015 Paris, France. Phone: 33 1 45 68 88 99. Fax: 33 1 40 61 32 98. E-mail: florence{at}pasteur.fr.

Journal of Virology, May 2001, p. 4941-4946, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4941-4946.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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