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Journal of Virology, May 2001, p. 4918-4921, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4918-4921.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Echoviruses Bind Heparan Sulfate at the Cell Surface

Ian G. Goodfellow,1 Amir Babak Sioofy,1 Robert M. Powell,2 and David J. Evans1,*

Division of Virology, Institute of Biomolecular and Life Sciences, University of Glasgow, Glasgow,1 and AMS, The University of Reading, Whiteknights, Reading RG6 5AJ,2 United Kingdom

Received 6 November 2000/Accepted 7 February 2001

Some echoviruses (EV) that bind decay-accelerating factor (DAF) also bind cells of human and murine origins in a DAF-independent manner. Pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain EV, including several low-passage clinical isolates of EV 6 and some EV that do not bind DAF. These studies suggest that heparan sulfate may be of in vivo relevance as an attachment molecule for EV.

* Corresponding author. Mailing address: Institute of Virology, University of Glasgow, Church St., Glasgow G11 5JR, United Kingdom. Phone: 44 (0)141 330 6249. Fax: 44 (0)141 330 6249. E-mail: David.Evans{at}vir.gla.ac.uk.

Journal of Virology, May 2001, p. 4918-4921, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4918-4921.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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