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Journal of Virology, May 2001, p. 4907-4911, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4907-4911.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Persistence of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Clones in a Subject with Rapid Disease Progression

Sabina A. Islam,1 Christine M. Hay,2 Kelly E. Hartman,1 Suqin He,1 Amy K. Shea,1 Alicja K. Trocha,1 Mark J. Dynan,1 Neha Reshamwala,1 Susan P. Buchbinder,3 Nesli O. Basgoz,1 and Spyros A. Kalams1,*

Partners AIDS Research Center & ID Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 021141; New York Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, New York 100322; and AIDS Office, Department of Public Health, San Francisco, California 941403

Received 12 July 2000/Accepted 20 February 2001

We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection.

* Corresponding author. Mailing address: MGH-East, CNY 5212, 149 13th St., Charlestown, MA 02129. Phone: (617) 726-8166. Fax: (617) 726-4691. E-mail: Kalams{at}helix.mgh.harvard.edu.

Journal of Virology, May 2001, p. 4907-4911, Vol. 75, No. 10
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.10.4907-4911.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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