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Journal of Virology, May 2001, p. 4843-4853, Vol. 75, No. 10
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.10.4843-4853.2001
Transcription Program of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)
Mini
Paulose-Murphy,1
Nguyen-Khoi
Ha,1
Chunsheng
Xiang,1
Yidong
Chen,2
Laura
Gillim,1
Robert
Yarchoan,1
Paul
Meltzer,2
Michael
Bittner,2
Jeffrey
Trent,2 and
Steven
Zeichner1,*
HIV and AIDS Malignancy Branch, National
Cancer Institute,1 and Cancer Genetics
Branch, National Human Genome Research
Institute,2 National Institutes of Health,
Bethesda, Maryland 20892
Received 15 November 2000/Accepted 16 February 2001
Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in
Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease,
encodes several pathogenically important cellular homologs. To define
the HHV-8 transcription program, RNA obtained from latently infected
body cavity-based lymphoma 1 cells induced to undergo lytic replication
was used to query a custom HHV-8 DNA microarray containing nearly every
known viral open reading frame. The patterns of viral gene expression
offer insights into the replication and pathogenic strategies of HHV-8.
*
Corresponding author. Mailing address: NIH, NCI, Bldg.
10, Room 10S255, MSC 1868, Bethesda, MD 20892-1868. Phone: (301)
402-3637. Fax: (301) 480-8250. E-mail: zeichner{at}nih.gov.
Journal of Virology, May 2001, p. 4843-4853, Vol. 75, No. 10
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.10.4843-4853.2001
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