Transcription Program of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)

doi:10.1128/JVI.75.10.4843-4853.2001

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Journal of Virology, May 2001, p. 4843-4853, Vol. 75, No. 10
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.10.4843-4853.2001

Transcription Program of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)

Mini Paulose-Murphy,¹ Nguyen-Khoi Ha,¹ Chunsheng Xiang,¹ Yidong Chen,² Laura Gillim,¹ Robert Yarchoan,¹ Paul Meltzer,² Michael Bittner,² Jeffrey Trent,² and Steven Zeichner¹^,^*

HIV and AIDS Malignancy Branch, National Cancer Institute,¹ and Cancer Genetics Branch, National Human Genome Research Institute,² National Institutes of Health, Bethesda, Maryland 20892

Received 15 November 2000/Accepted 16 February 2001

Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman'sdisease, encodes several pathogenically important cellular homologs.To define the HHV-8 transcription program, RNA obtained from latentlyinfected body cavity-based lymphoma 1 cells induced to undergolytic replication was used to query a custom HHV-8 DNA microarraycontaining nearly every known viral open reading frame. The patternsof viral gene expression offer insights into the replication andpathogenic strategies of HHV-8.

^* Corresponding author. Mailing address: NIH, NCI, Bldg. 10, Room 10S255, MSC 1868, Bethesda, MD 20892-1868. Phone: (301) 402-3637.Fax: (301) 480-8250. E-mail: zeichner{at}nih.gov.

Journal of Virology, May 2001, p. 4843-4853, Vol. 75, No. 10
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.10.4843-4853.2001

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