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Journal of Virology, January 2001, p. 544-547, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.544-547.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Induction of Polyomavirus-Specific CD8+ T Lymphocytes by Distinct Dendritic Cell Subpopulations

Donald R. Drake III,1,dagger Mandy L. Shawver,1 Annette Hadley,1 Eric Butz,2 Charles Maliszewski,2 and Aron E. Lukacher1,*

Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322,1 and Immunex Corporation, Seattle, Washington 981012

Received 28 July 2000/Accepted 25 September 2000

Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset are permissive for infection by mouse polyomavirus and, when loaded with a peptide corresponding to the immunodominant anti-polyomavirus CD8+ T-cell epitope or infected by polyomavirus, are each capable of driving expansion of primary polyomavirus-specific CD8+ T-cell responses in vivo.

* Corresponding author. Mailing address: Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, 1639 Pierce Dr., Atlanta, GA 30322. Phone: (404) 727-1896. Fax: (404) 727-5764. E-mail: alukach{at}emory.edu.

dagger Present address: Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908.

Journal of Virology, January 2001, p. 544-547, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.544-547.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.