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Journal of Virology, January 2001, p. 540-543, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.540-543.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Direct Ex Vivo Measurement of CD8+ T-Lymphocyte Responses to Human Parvovirus B19

T. Tolfvenstam,1 A. Oxenius,2 D. A. Price,2 B. L. Shacklett,3 H. M. L. Spiegel,3 K. Hedman,4 O. Norbeck,1 M. Levi,5 K. Olsen,2 M. Kantzanou,2 D. F. Nixon,3 K. Broliden,1 and P. Klenerman2,*

Department of Virology, Karolinska Institute, Stockholm, Sweden1; Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom2; Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 100163; Department of Virology, Haartman Institute, University of Helsinki, SF-00014 Helsinki, Finland4; and Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden5

Received 1 June 2000/Accepted 28 September 2000

Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8+ T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.

* Corresponding author. Mailing address: Nuffield Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. Phone: 44 1865 221335. Fax: 441865 220993. E-mail: klener{at}molbiol.ox.ac.uk.

Journal of Virology, January 2001, p. 540-543, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.540-543.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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