Journal of Virology, January 2001, p. 540-543, Vol. 75, No. 1
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.1.540-543.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Department of Virology, Karolinska Institute, Stockholm, Sweden1; Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom2; Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 100163; Department of Virology, Haartman Institute, University of Helsinki, SF-00014 Helsinki, Finland4; and Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden5
Received 1 June 2000/Accepted 28 September 2000
Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8+ T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.
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