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Journal of Virology, January 2001, p. 522-526, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.522-526.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Tissue Distribution and Timing of Appearance of Polytropic Envelope Recombinants during Infection with SL3-3 Murine Leukemia Virus or Its Weakly Pathogenic SL3Delta Myb5 Mutant

Karen Rulli,1,2 Patricia A. Lobelle-Rich,1 Alla Trubetskoy,3 Jack Lenz,3 and Laura S. Levy1,2,*

Department of Microbiology and Immunology1 and Program in Molecular and Cellular Biology,2 Tulane University School of Medicine, New Orleans, Louisiana 70112, and Department of Molecular Genetics, Albert Einstein School of Medicine, Bronx, New York 104613

Received 2 June 2000/Accepted 26 September 2000

A time course analysis was performed to identify the sites of formation and timing of appearance of polytropic recombinant viruses following infection of NIH/Swiss mice with the murine retrovirus SL3-3 murine leukemia virus (SL3) or with a weakly pathogenic mutant termed SL3Delta Myb5. The results indicated that (i) polytropic recombinant viruses occur initially in the thymus of SL3-infected animals, (ii) the timing of appearance of polytropic recombinants in bone marrow is not consistent with their participation in the previously reported formation of transplantable tumor-forming cells at 3 to 4 week postinoculation, and (iii) the efficient generation of recombinant virus is correlated with efficient tumor induction.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave., SL-38, New Orleans, LA, 70112. Phone: (504) 587-2083. Fax: (504) 588-5144. E-mail: llevy{at}tulane.edu.

Journal of Virology, January 2001, p. 522-526, Vol. 75, No. 1
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.1.522-526.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.