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Journal of Virology, May 2000, p. 4420-4424, Vol. 74, No. 9
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Retroviral Vector Targeting to Human Immunodeficiency Virus Type 1-Infected Cells by Receptor Pseudotyping

Nikunj V. Somia, Hiroyuki Miyoshi, Mark J. Schmitt, and Inder M. Verma*

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037

Received 12 October 1999/Accepted 21 January 2000

We report the generation of retroviral vectors based on Moloney murine leukemia virus that specifically transduce cells infected with T-cell-tropic human immunodeficiency virus type 1 (HIV-1). This vector was pseudotyped with T-cell-tropic HIV-1 receptors CD4 and CXCR4. We demonstrate that transduction is contingent upon HIV-1 gp120 and gp41 expression.

* Corresponding author. Mailing address: Laboratory of Genetics, The Salk Institute for Biological Studies, P.O. Box 85800, San Diego, CA 92186-5800. Phone: (858) 453-4100, ext. 1462. Fax: (858) 558-7454. E-mail: verma{at}salk.edu.

Journal of Virology, May 2000, p. 4420-4424, Vol. 74, No. 9
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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