This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Henke, A.
Right arrow Articles by Munder, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Henke, A.
Right arrow Articles by Munder, T.

 Previous Article  |  Next Article 

Journal of Virology, May 2000, p. 4284-4290, Vol. 74, No. 9
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Apoptosis in Coxsackievirus B3-Caused Diseases: Interaction between the Capsid Protein VP2 and the Proapoptotic Protein Siva

Andreas Henke,1,* Heike Launhardt,2 Katrin Klement,1 Axel Stelzner,1 Roland Zell,1 and Thomas Munder2

Institute of Virology, Medical Center, Friedrich Schiller University Jena,1 and Department of Cell and Molecular Biology, Hans-Knöll-Institut für Naturstoff-Forschung e.V., D-07745 Jena,2 Germany

Received 8 November 1999/Accepted 28 January 2000

Coxsackievirus B3 (CVB3) is a common factor in human myocarditis. Apoptotic events are present in CVB3-induced disease, but it is unclear how CVB3 is involved in apoptosis and which viral proteins may induce the apoptotic pathway. In this report we demonstrate that the human and murine proapoptotic protein Siva specifically interact with the CVB3 capsid protein VP2. Furthermore, the transcription of Siva is strongly induced in tissue of CVB3-infected mice and is present in the same area which is positively stained for apoptosis, CD27, and CD70. It has been proposed that Siva is involved in the CD27/CD70-transduced apoptosis. Therefore, we suggest a molecular mechanism through which apoptotic events contributes to CVB3-caused pathogenesis.

* Corresponding author. Mailing address: Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str. 10, D-07745 Jena, Germany. Phone: (49) 3641 657215. Fax: (49) 3641 657202. E-mail: i6hean{at}rz.uni-jena.de.

Journal of Virology, May 2000, p. 4284-4290, Vol. 74, No. 9
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Lidsky, P. V., Romanova, L. I., Kolesnikova, M. S., Bardina, M. V., Khitrina, E. V., Hato, S. V., van Kuppeveld, F. J. M., Agol, V. I. (2009). Interactions between Viral and Prokaryotic Pathogens in a Mixed Infection with Cardiovirus and Mycoplasma. J. Virol. 83: 9940-9951 [Abstract] [Full Text]  
  • Cottle, D. L., McGrath, M. J., Wilding, B. R., Cowling, B. S., Kane, J. M., D'Arcy, C. E., Holdsworth, M., Hatzinisiriou, I., Prescott, M., Brown, S., Mitchell, C. A. (2009). SLIMMER (FHL1B/KyoT3) Interacts with the Proapoptotic Protein Siva-1 (CD27BP) and Delays Skeletal Myoblast Apoptosis. J. Biol. Chem. 284: 26964-26977 [Abstract] [Full Text]  
  • Chikhalya, A., Luu, D. D., Carrera, M., De La Cruz, A., Torres, M., Martinez, E. N., Chen, T., Stephens, K. D., Haas-Stapleton, E. J. (2009). Pathogenesis of Autographa californica multiple nucleopolyhedrovirus in fifth-instar Anticarsia gemmatalis larvae. J. Gen. Virol. 90: 2023-2032 [Abstract] [Full Text]  
  • Resch, U., Schichl, Y. M., Winsauer, G., Gudi, R., Prasad, K., de Martin, R. (2009). Siva1 is a XIAP-interacting protein that balances NF{kappa}B and JNK signalling to promote apoptosis. J. Cell Sci. 122: 2651-2661 [Abstract] [Full Text]  
  • Romanova, L. I., Lidsky, P. V., Kolesnikova, M. S., Fominykh, K. V., Gmyl, A. P., Sheval, E. V., Hato, S. V., van Kuppeveld, F. J. M., Agol, V. I. (2009). Antiapoptotic Activity of the Cardiovirus Leader Protein, a Viral "Security" Protein. J. Virol. 83: 7273-7284 [Abstract] [Full Text]  
  • Fan, J., Son, K.-N., Arslan, S. Y., Liang, Z., Lipton, H. L. (2009). Theiler's Murine Encephalomyelitis Virus Leader Protein Is the Only Nonstructural Protein Tested That Induces Apoptosis When Transfected into Mammalian Cells. J. Virol. 83: 6546-6553 [Abstract] [Full Text]  
  • Mihatsch, K., Nestler, M., Saluz, H.-P., Henke, A., Munder, T. (2009). Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection. Cardiovasc Res 81: 108-115 [Abstract] [Full Text]  
  • Rassmann, A., Henke, A., Zobawa, M., Carlsohn, M., Saluz, H.-P., Grabley, S., Lottspeich, F., Munder, T. (2006). Proteome alterations in human host cells infected with coxsackievirus B3. J. Gen. Virol. 87: 2631-2638 [Abstract] [Full Text]  
  • Zhang, H. M., Yuan, J., Cheung, P., Chau, D., Wong, B. W., McManus, B. M., Yang, D. (2005). Gamma Interferon-Inducible Protein 10 Induces HeLa Cell Apoptosis through a p53-Dependent Pathway Initiated by Suppression of Human Papillomavirus Type 18 E6 and E7 Expression. Mol. Cell. Biol. 25: 6247-6258 [Abstract] [Full Text]  
  • Chu, F., Barkinge, J., Hawkins, S., Gudi, R., Salgia, R., Kanteti, P. V.S. (2005). Expression of Siva-1 Protein or Its Putative Amphipathic Helical Region Enhances Cisplatin-Induced Apoptosis in Breast Cancer Cells: Effect of Elevated Levels of BCL-2. Cancer Res. 65: 5301-5309 [Abstract] [Full Text]  
  • Merl, S., Michaelis, C., Jaschke, B., Vorpahl, M., Seidl, S., Wessely, R. (2005). Targeting 2A Protease by RNA Interference Attenuates Coxsackieviral Cytopathogenicity and Promotes Survival in Highly Susceptible Mice. Circulation 111: 1583-1592 [Abstract] [Full Text]  
  • Feuer, R., Pagarigan, R. R., Harkins, S., Liu, F., Hunziker, I. P., Whitton, J. L. (2005). Coxsackievirus Targets Proliferating Neuronal Progenitor Cells in the Neonatal CNS. J. Neurosci. 25: 2434-2444 [Abstract] [Full Text]  
  • Kim, S.-M., Park, J.-H., Chung, S.-K., Kim, J.-Y., Hwang, H.-Y., Chung, K.-C., Jo, I., Park, S.-I., Nam, J.-H. (2004). Coxsackievirus B3 Infection Induces cyr61 Activation via JNK To Mediate Cell Death. J. Virol. 78: 13479-13488 [Abstract] [Full Text]  
  • Py, B., Slomianny, C., Auberger, P., Petit, P. X., Benichou, S. (2004). Siva-1 and an Alternative Splice Form Lacking the Death Domain, Siva-2, Similarly Induce Apoptosis in T Lymphocytes via a Caspase-Dependent Mitochondrial Pathway. J. Immunol. 172: 4008-4017 [Abstract] [Full Text]  
  • Del Rio, M., Imam, A., DeLeon, M., Gomez, G., Mishra, J., Ma, Q., Parikh, S., Devarajan, P. (2004). The Death Domain of Kidney Ankyrin Interacts with Fas and Promotes Fas-Mediated Cell Death in Renal Epithelia. J. Am. Soc. Nephrol. 15: 41-51 [Abstract] [Full Text]  
  • Feuer, R., Mena, I., Pagarigan, R. R., Harkins, S., Hassett, D. E., Whitton, J. L. (2003). Coxsackievirus B3 and the Neonatal CNS: The Roles of Stem Cells, Developing Neurons, and Apoptosis in Infection, Viral Dissemination, and Disease. Am. J. Pathol. 163: 1379-1393 [Abstract] [Full Text]  
  • Colon-Ramos, D. A., Irusta, P. M., Gan, E. C., Olson, M. R., Song, J., Morimoto, R. I., Elliott, R. M., Lombard, M., Hollingsworth, R., Hardwick, J. M., Smith, G. K., Kornbluth, S. (2003). Inhibition of Translation and Induction of Apoptosis by Bunyaviral Nonstructural Proteins Bearing Sequence Similarity to Reaper. Mol. Biol. Cell 14: 4162-4172 [Abstract] [Full Text]  
  • Klingel, K., Schnorr, J.-J., Sauter, M., Szalay, G., Kandolf, R. (2003). {beta}2-Microglobulin-Associated Regulation of Interferon-{gamma} and Virus-Specific Immunoglobulin G Confer Resistance Against the Development of Chronic Coxsackievirus Myocarditis. Am. J. Pathol. 162: 1709-1720 [Abstract] [Full Text]  
  • Zhang, H. M., Yanagawa, B., Cheung, P., Luo, H., Yuan, J., Chau, D., Wang, A., Bohunek, L., Wilson, J. E., McManus, B. M., Yang, D. (2002). Nip21 Gene Expression Reduces Coxsackievirus B3 Replication by Promoting Apoptotic Cell Death via a Mitochondria-Dependent Pathway. Circ. Res. 90: 1251-1258 [Abstract] [Full Text]  
  • Kuo, R.-L., Kung, S.-H., Hsu, Y.-Y., Liu, W.-T. (2002). Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death. J. Gen. Virol. 83: 1367-1376 [Abstract] [Full Text]  
  • Xue, L., Chu, F., Cheng, Y., Sun, X., Borthakur, A., Ramarao, M., Pandey, P., Wu, M., Schlossman, S. F., Prasad, K. V. S. (2002). Siva-1 binds to and inhibits BCL-XL-mediated protection against UV radiation-induced apoptosis. Proc. Natl. Acad. Sci. USA 99: 6925-6930 [Abstract] [Full Text]  
  • Luo, H., Yanagawa, B., Zhang, J., Luo, Z., Zhang, M., Esfandiarei, M., Carthy, C., Wilson, J. E., Yang, D., McManus, B. M. (2002). Coxsackievirus B3 Replication Is Reduced by Inhibition of the Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway. J. Virol. 76: 3365-3373 [Abstract] [Full Text]  
  • Henke, A., Zell, R., Ehrlich, G., Stelzner, A. (2001). Expression of Immunoregulatory Cytokines by Recombinant Coxsackievirus B3 Variants Confers Protection against Virus-Caused Myocarditis. J. Virol. 75: 8187-8194 [Abstract] [Full Text]  
  • Jelachich, M. L., Lipton, H. L. (2001). Theiler's Murine Encephalomyelitis Virus Induces Apoptosis in Gamma Interferon-Activated M1 Differentiated Myelomonocytic Cells through a Mechanism Involving Tumor Necrosis Factor Alpha (TNF-{alpha}) and TNF-{alpha}-Related Apoptosis-Inducing Ligand. J. Virol. 75: 5930-5938 [Abstract] [Full Text]  
  • Peng, T., Sadusky, T., Li, Y., Coulton, G. R., Zhang, H., Archard, L. C. (2001). Altered expression of Bag-1 in Coxsackievirus B3 infected mouse heart. Cardiovasc Res 50: 46-55 [Abstract] [Full Text]  
  • Cao, C., Ren, X., Kharbanda, S., Koleske, A., Prasad, K. V. S., Kufe, D. (2001). The ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress. J. Biol. Chem. 276: 11465-11468 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»