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Journal of Virology, May 2000, p. 4064-4073, Vol. 74, No. 9
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Isolation and Characterization of an Equine Foamy Virus

Joelle Tobaly-Tapiero,1 Patricia Bittoun,1 Manuel Neves,1 Marie-Claude Guillemin,1 Charles-Henri Lecellier,1 Francine Puvion-Dutilleul,2 Bernard Gicquel,3 Stephan Zientara,3 Marie-Louise Giron,1 Hugues de Thé, and Ali Saïb1,*

CNRS UPR9051, Université Paris 7, Hôpital Saint-Louis, 75475 Paris Cedex 10,1 CNRS UPR1983, 94801 Villejuif Cedex,2 and Agence Française de Sécurité Sanitaire des Aliments, 94703 Maisons-Alfort,3 France

Received 10 November 1999/Accepted 21 January 2000

Foamy viruses (FVs) are complex retroviruses which have been isolated from different animal species including nonhuman primates, cattle, and cats. Here, we report the isolation and characterization of a new FV isolated from blood samples of horses. Similar to other FVs, the equine foamy virus (EFV) exhibits a highly characteristic ultrastructure and induces syncytium formation and subsequent cell lysis on a large number of cell lines. Molecular cloning of EFV reveals that the general organization is that of other known FVs, whereas sequence similarity with its bovine FV counterpart is only 40%. Interestingly, EFV buds exclusively from the plasma membrane and not from the endoplasmic reticulum (ER), as previously shown for other FVs. The absence of the ER retrieval dilysine motif in EFV Env is likely responsible for this unexpected sorting pathway.

* Corresponding author. Mailing address: CNRS UPR9051, Université Paris 7, Hôpital Saint-Louis, 75475 Paris Cedex 10, France. Phone: 33-1-53-72-40-96. Fax: 33-1-53-72-40-90. E-mail: alisaib{at}infobiogen.fr.

Journal of Virology, May 2000, p. 4064-4073, Vol. 74, No. 9
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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