Induction of a Novel Cellular Homolog of Interleukin-10, AK155, by Transformation of T Lymphocytes with Herpesvirus Saimiri

doi:10.1128/JVI.74.8.3881-3887.2000

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Journal of Virology, April 2000, p. 3881-3887, Vol. 74, No. 8
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Induction of a Novel Cellular Homolog of Interleukin-10, AK155, by Transformation of T Lymphocytes with Herpesvirus Saimiri

Andrea Knappe, Simon Hör, Sabine Wittmann, and Helmut Fickenscher^*

Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany

Received 24 November 1999/Accepted 18 January 2000

Although herpesvirus saimiri-transformed T lymphocytes retain multiple normal T-cell functions, only a few changes have beendescribed. By subtractive hybridization, we have isolated a novelcellular gene, ak155, a sequence homolog of the interleukin-10gene. Specifically herpesvirus saimiri-transformed T cells overexpressak155 and secrete the protein into the supernatant. In other T-celllines and in native peripheral blood cells, but not in B cells,ak155 is transcribed at low levels. AK155 forms homodimers similarlyto interleukin-10. As a lymphokine, AK155 may contribute to thetransformed phenotype of human T cells after infection by herpesvirussaimiri.

^* Corresponding author. Mailing address: Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-UniversitätErlangen-Nürnberg, Schlossgarten 4, D-91054 Erlangen, Germany.Phone: 49-9131-85-23786. Fax: 49-9131-85-26493. E-mail: fickenscher{at}viro.med.uni-erlangen.de.

Present address: Bavarian Nordic Research Institute GmbH, D-82152 Martinsried,Germany.

Journal of Virology, April 2000, p. 3881-3887, Vol. 74, No. 8
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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