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Journal of Virology, April 2000, p. 3449-3454, Vol. 74, No. 8
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Virus Load and Sequence Variation in Simian Retrovirus Type 2 Infection

Lisa L. Rosenblum,1,* Robin A. Weiss,2 and Myra O. McClure1

Jefferiss Research Trust Laboratories, Imperial College of School of Medicine at St. Mary's, London W2 1NY,1 and Windeyer Institute of Medical Sciences, London W1P 6DB,2 United Kingdom

Received 21 October 1999/Accepted 11 January 2000

The natural history of type D simian retrovirus (SRV) infection is poorly characterized in terms of viral load, antibody status, and sequence variation. To investigate this, blood samples were taken from a small cohort of mostly asymptomatic cynomolgus macaques (Macaca fascicularis), naturally infected with SRV type 2 (SRV-2), some of which were followed over an 8-month period with blood taken every 2 months. Provirus and RNA virus loads were obtained, the samples were screened for presence of antibodies to SRV-2 and neutralizing antibody titers to SRV-2 were assayed. env sequences were aligned to determine intra- and intermonkey variation over time. Virus loads varied greatly among cohort individuals but, conversely, remained steady for each macaque over the 8-month period, regardless of their initial levels. No significant sequence variation was found within an individual over time. No clear picture emerged from these results, which indicate that the variables of SRV-2 infection are complex, differ from those for lentivirus infection, and are not distinctly related to disease outcome.

* Corresponding author. Mailing address: Jefferiss Research Trust Laboratories, Imperial College School Medicine at St. Mary's, Praed St., London W2 1NY, United Kingdom. Phone: 44-171-886-6648. Fax: 44-171-886-6645. E-mail: L.Rosenblum{at}ic.ac.uk.

Journal of Virology, April 2000, p. 3449-3454, Vol. 74, No. 8
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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