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Journal of Virology, April 2000, p. 3423-3426, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Uncoating Kinetics of Hepatitis A Virus Virions and Provirions

Naomi E. Bishop* and David A. Anderson

Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia 3078

Received 6 July 1999/Accepted 22 December 1999

When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection. It is proposed that the heterogenous mixture of infectious hepatitis A virus particles (virions and provirions) typically present in inocula is responsible for the normally asynchronous nature of hepatitis A virus uncoating kinetics.

* Corresponding author. Present address: School of Biological Sciences, Division of Biochemistry, 2.205 Stopford Building, Oxford Rd., Manchester M13 9PT, United Kingdom. Phone: 44 161 275 5955. Fax: 44 161 275 5082. E-mail: nebishop{at}fs2.scg.man.ac.uk.

Journal of Virology, April 2000, p. 3423-3426, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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