This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ward, T.
Right arrow Articles by Evans, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ward, T.
Right arrow Articles by Evans, D. J.

 Previous Article  |  Next Article 

Journal of Virology, April 2000, p. 3410-3412, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Fatty Acid-Depleted Albumin Induces the Formation of Echovirus A Particles

Trevor Ward,1,2 Robert M. Powell,2 Yasmin Chaudhry,1 Janet Meredith,2 Jeffrey W. Almond,2,dagger Werner Kraus,3 Birgit Nelsen-Salz,3 Hans J. Eggers,3 and David J. Evans1,*

Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, United Kingdom1; School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom2; and Institut für Virologie der Universität zu Köln, 50935 Cologne, Germany3

Received 3 September 1999/Accepted 21 December 1999

Picornavirus infection requires virus uncoating, associated with the production of 135S "A" particles and 80S empty particles from 160S mature virions, to release the RNA genome into the cell cytoplasm. Normal albumin inhibits this process. We now show that when depleted of fatty acids, albumin induces the formation of echovirus A particles.

* Corresponding author. Mailing address: Institute of Virology, University of Glasgow, Church St., Glasgow G11 5JR, United Kingdom. Phone and fax: 44 (0) 141 330 6249. E-mail: David.Evans{at}vir.gla.ac.uk.

dagger Present address: Pasteur Mérieux Connaught, 69280 Marcy-L'Etoile, France.

Journal of Virology, April 2000, p. 3410-3412, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Tuthill, T. J., Bubeck, D., Rowlands, D. J., Hogle, J. M. (2006). Characterization of Early Steps in the Poliovirus Infection Process: Receptor-Decorated Liposomes Induce Conversion of the Virus to Membrane-Anchored Entry-Intermediate Particles. J. Virol. 80: 172-180 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»