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Journal of Virology, April 2000, p. 3410-3412, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Fatty Acid-Depleted Albumin Induces the Formation of Echovirus A Particles

Trevor Ward,1,2 Robert M. Powell,2 Yasmin Chaudhry,1 Janet Meredith,2 Jeffrey W. Almond,2,dagger Werner Kraus,3 Birgit Nelsen-Salz,3 Hans J. Eggers,3 and David J. Evans1,*

Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, United Kingdom1; School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom2; and Institut für Virologie der Universität zu Köln, 50935 Cologne, Germany3

Received 3 September 1999/Accepted 21 December 1999

Picornavirus infection requires virus uncoating, associated with the production of 135S "A" particles and 80S empty particles from 160S mature virions, to release the RNA genome into the cell cytoplasm. Normal albumin inhibits this process. We now show that when depleted of fatty acids, albumin induces the formation of echovirus A particles.

* Corresponding author. Mailing address: Institute of Virology, University of Glasgow, Church St., Glasgow G11 5JR, United Kingdom. Phone and fax: 44 (0) 141 330 6249. E-mail: David.Evans{at}vir.gla.ac.uk.

dagger Present address: Pasteur Mérieux Connaught, 69280 Marcy-L'Etoile, France.

Journal of Virology, April 2000, p. 3410-3412, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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