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Journal of Virology, April 2000, p. 3404-3409, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon

Raj Deonarain,1 Antonio Alcamí,2 Maria Alexiou,1 Margaret J. Dallman,3 Dirk R. Gewert,4,* and Andrew C. G. Porter1,*

MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN,1 Division of Virology, Department of Pathology, Cambridge University, Cambridge CB2 1QP,2 Department of Biology, Imperial College of Science Technology and Medicine, South Kensington, London SW7 2AZ,3 and QT Genetics Ltd., Cambridge CB4 3GA,4 United Kingdom

Received 8 September 1999/Accepted 30 December 1999

We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.

* Corresponding authors. Mailing address for Andrew C. G. Porter: Gene Targeting Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Rd., London W12 ONN, United Kingdom. Phone: 44 181 383 8276. Fax: 44 181 383 8303. E-mail: andy.porter{at}csc.mrc.ac.uk. Phone for D. R. Gewert: 44 223 575527. Fax: 44 223 575528. E-mail: gewert{at}dialstart.net.

Journal of Virology, April 2000, p. 3404-3409, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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