Journal of Virology, April 2000, p. 3404-3409, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN,1 Division of Virology, Department of Pathology, Cambridge University, Cambridge CB2 1QP,2 Department of Biology, Imperial College of Science Technology and Medicine, South Kensington, London SW7 2AZ,3 and QT Genetics Ltd., Cambridge CB4 3GA,4 United Kingdom
Received 8 September 1999/Accepted 30 December 1999
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.
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