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Journal of Virology, April 2000, p. 3404-3409, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Impaired Antiviral Response and Alpha/Beta
Interferon Induction in Mice Lacking Beta Interferon
Raj
Deonarain,1
Antonio
Alcamí,2
Maria
Alexiou,1
Margaret J.
Dallman,3
Dirk R.
Gewert,4,* and
Andrew
C. G.
Porter1,*
MRC Clinical Science Centre, Imperial College
School of Medicine, Hammersmith Hospital, London W12
ONN,1 Division of Virology, Department
of Pathology, Cambridge University, Cambridge CB2
1QP,2 Department of Biology,
Imperial College of Science Technology and Medicine, South Kensington,
London SW7 2AZ,3 and QT Genetics
Ltd., Cambridge CB4 3GA,4 United Kingdom
Received 8 September 1999/Accepted 30 December 1999
We have generated mice lacking the gene for beta interferon and
report that they are highly susceptible to vaccinia virus infection.
Furthermore, in cultured embryo fibroblasts, viral induction of alpha
interferon and of 2-5A synthetase genes is impaired. We also show that
beta interferon does not prime its own expression.
*
Corresponding authors. Mailing address for Andrew
C. G. Porter: Gene Targeting Group, MRC Clinical Sciences
Centre, Imperial College School of Medicine, Hammersmith Hospital, Du
Cane Rd., London W12 ONN, United Kingdom. Phone: 44 181 383 8276. Fax:
44 181 383 8303. E-mail:
andy.porter{at}csc.mrc.ac.uk. Phone for D. R. Gewert:
44 223 575527. Fax: 44 223 575528. E-mail: gewert{at}dialstart.net.
Journal of Virology, April 2000, p. 3404-3409, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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