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Journal of Virology, April 2000, p. 2967-2972, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Clink, a Nanovirus-Encoded Protein, Binds both pRB and SKP1

Marie N. Aronson,1 Alain D. Meyer,1,dagger Jànos Györgyey,1,Dagger Lina Katul,2 H. Josef Vetten,2 Bruno Gronenborn,1,* and Tatiana Timchenko1

Institut des Sciences Végétales, CNRS, 91198 Gif sur Yvette, France,1 and Biologische Bundesanstalt für Land und Forstwirtschaft, Institut für Pflanzenvirologie, Mikrobiologie und Biologische Sicherheit, D-38104 Braunschweig, Germany2

Received 5 August 1999/Accepted 22 December 1999

Clink, a 20-kDa protein of faba bean necrotic yellows virus, a single-stranded DNA plant virus, interacts with pRB family members and a SKP1 homologue from Medicago sativa. An LxCxE motif and an F-box of Clink mediate the interactions with the respective proteins. The capacity of Clink to bind pRB correlates with its ability to stimulate viral replication. Interaction of a single protein with the cell cycle regulator pRB and SKP1, a constituent of the ubiquitin-protein turnover pathway, appears to be a novel feature. Hence, Clink may represent a new class of viral cell cycle modulators.

* Corresponding author. Mailing address: Institut des Sciences Végétales, CNRS, 91198 Gif sur Yvette, France. Phone: 33 1 69 82 38 33. Fax: 33 1 69 82 36 95. E-mail: gronenborn{at}isv.cnrs-gif.fr.

dagger Present address: Abteilung für Pflanzenphysiologie, Botanisches Institut der Universität Basel, CH-4056 Basel, Switzerland.

Dagger Present address: Institute of Plant Biology, BRC, H-6701 Szeged, Hungary.

Journal of Virology, April 2000, p. 2967-2972, Vol. 74, No. 7
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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