This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kitchen, S. G.
Right arrow Articles by Zack, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kitchen, S. G.
Right arrow Articles by Zack, J. A.

 Previous Article  |  Next Article 

Journal of Virology, March 2000, p. 2943-2948, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Functional Reconstitution of Thymopoiesis after Human Immunodeficiency Virus Infection

Scott G. Kitchen,1 Scott Killian,2 Janis V. Giorgi,1 and Jerome A. Zack1,3,*

Division of Hematology-Oncology, Department of Medicine and UCLA AIDS Institute,1 and Department of Microbiology and Molecular Genetics,3 UCLA School of Medicine, and Department of Epidemiology, UCLA School of Public Health,2 Los Angeles, California 90095

Received 18 October 1999/Accepted 8 December 1999

We have utilized combination antiretroviral therapy following human immunodeficiency virus type 1-induced human CD4+ thymocyte depletion in the SCID-hu mouse to examine the immune competence of reconstituting thymocytes which appear following administration of combination therapy. These cells express a normal distribution of T-cell receptor variable gene families and are responsive to costimulatory signals. These results suggest that normal thymic function may be restored following antiretroviral treatment.

* Corresponding author. Mailing address: Division of Hematology-Oncology, Department of Medicine, 11-934 Factor, 10833 Le Conte Ave., Los Angeles, CA 90095. Phone: (310) 794-7765. Fax: (310) 825-6192. E-mail: jzack{at}ucla.edu.

Journal of Virology, March 2000, p. 2943-2948, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»