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Journal of Virology, March 2000, p. 2900-2902, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Superantigen Expression Is Driven by Both Mouse Mammary Tumor Virus Long Terminal Repeat-Associated Promoters in Transgenic Mice

Brian Salmons,1 Thomas Miethke,2 Stefan Wintersperger,3 Mathias Müller,4 Gottfried Brem,4 and Walter H. Günzburg3,5,*

Bavarian Nordic, D-82152 Martinsried,1 Institute for Microbiology and Hygiene, Technical University, D-80539 Munich,2 and Institute of Molecular Virology, GSF-Neuherberg, D-85758 Oberschleissheim,3 Germany, and Institute of Animal Breeding and Genetics4 and Institute of Virology,5 University of Veterinary Sciences, A-1210 Vienna, Austria

Received 9 November 1999/Accepted 15 December 1999

In addition to the usual retroviral promoter, the mouse mammary tumor virus (MMTV) long terminal repeat carries a second promoter located in the U3 region. Here we show that both of these promoters are independently able to give rise to superantigen activity in transgenic mice. The ability of multiple MMTV promoters to drive superantigen expression underscores its importance in the virus life cycle.

* Corresponding author. Mailing address: Institute of Virology, University of Veterinary Sciences, Josef-Baumann-Gasse 1, A-1210 Vienna, Austria. Phone: 43-1-25077-2301. Fax: 43-1-25077-2390. E-mail: walter.guenzburg{at}vu-wien.ac.at.

Journal of Virology, March 2000, p. 2900-2902, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Rouault, F., Nejad Asl, S. B., Rungaldier, S., Fuchs, E., Salmons, B., Gunzburg, W. H. (2007). Promoter Complex in the Central Part of the Mouse Mammary Tumor Virus Long Terminal Repeat. J. Virol. 81: 12572-12581 [Abstract] [Full Text]  


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