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Journal of Virology, March 2000, p. 2895-2899, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Productive Replication of Human Adenoviruses in Mouse Epidermal Cells

Ian Ganly,1 Vivien Mautner,2 and Allan Balmain1,*

CRC Department of Medical Oncology, CRC Beatson Laboratories, Glasgow G61 1BD, Scotland,1 and CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, England,2 United Kingdom

Received 20 July 1999/Accepted 6 December 1999

In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.

* Corresponding author. Present address: UCSF Cancer Center, 2340 Sutter St., San Francisco, CA 94143. Phone: (415) 502 4192. Fax: (415) 502 6779. E-mail: abalmain{at}cc.ucsf.edu.

Journal of Virology, March 2000, p. 2895-2899, Vol. 74, No. 6
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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