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Journal of Virology, March 2000, p. 2477-2480, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Sendai Virus Blocks Alpha Interferon Signaling to Signal Transducers and Activators of Transcription

Takayuki Komatsu,1,* Kenji Takeuchi,1 Junko Yokoo,2 Yukie Tanaka,3 and Bin Gotoh1

Department of Microbiology,1 Radioisotope Research Institute,2 and Central Research Laboratories,3 Fukui Medical University School of Medicine, Yoshida-gun, Fukui 910-1193, Japan

Received 24 September 1999/Accepted 1 December 1999

We demonstrate here that Sendai virus (SeV) blocks alpha interferon (IFN-alpha ) signaling to signal transducers and activators of transcription (STATs) in HeLa cells. IFN-alpha -stimulated tyrosine phosphorylation of STATs and subsequent formation of the IFN-stimulated gene factor 3 transcription complex were inhibited in SeV-infected cells, resulting in inefficient induction of IFN-stimulated gene products. None of the components of the signaling pathway---type I IFN receptor subunits Jak1, Tyk2, Stat1, Stat2, and p48---was degraded. Moreover, tyrosine phosphorylation of Jak1 in response to IFN-alpha was unaffected at the early phase of infection, suggesting that oligomerization of the receptor subunits proceeded normally. In contrast to Jak1, IFN-alpha -stimulated tyrosine phosphorylation of Tyk2 was partially inhibited. Therefore, this partial inhibition of activation of Tyk2 probably contributes to the subsequent failure in the activation of STATs.

* Corresponding author. Mailing address: Department of Microbiology, Fukui Medical University School of Medicine, Shimoaizuki 23-3, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan. Phone: 81 776 61 8324. Fax: 81 776 61 8104. E-mail: koma{at}fmsrsa.fukui-med.ac.jp.

Journal of Virology, March 2000, p. 2477-2480, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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