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Journal of Virology, March 2000, p. 2466-2471, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The c-myc Locus Is a Common Integration Site in Type B Retrovirus-Induced T-Cell Lymphomas

Lakshmi Rajan,1,dagger Dana Broussard,1 Mary Lozano,1 Chun G. Lee,2,Dagger Christine A. Kozak,2 and Jaquelin P. Dudley1,*

Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78705,1 and National Institute of Allergy and Infectious Diseases-LMM, National Institutes of Health, Bethesda, Maryland 208922

Received 13 August 1999/Accepted 12 November 1999

Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-myc overexpression by cis-acting effects at a distance.

* Corresponding author. Mailing address: Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 100 W. 24th St., Austin, TX 78705. Phone: (512) 471-8415. Fax: (512) 471-7088. E-mail: jdudley{at}uts.cc.utexas.edu.

dagger Present address: Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029.

Dagger Present address: Department of Internal Medicine, Yale University Medical School, New Haven, CT 06520.

Journal of Virology, March 2000, p. 2466-2471, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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