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Journal of Virology, March 2000, p. 2447-2450, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Contributions of Fas-Fas Ligand Interactions to the Pathogenesis of Mouse Hepatitis Virus in the Central Nervous System

Beatriz Parra,1 Mark T. Lin,2 Stephen A. Stohlman,1,3,* Cornelia C. Bergmann,1,3 Roscoe Atkinson,2,3 and David R. Hinton2,3

Departments of Molecular Microbiology and Immunology,1 Pathology,2 and Neurology,3 Keck School of Medicine, University of Southern California, Los Angeles, California 90033

Received 20 September 1999/Accepted 30 November 1999

The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.

* Corresponding author. Mailing address: University of Southern California, Keck School of Medicine, Department of Neurology, 1333 San Pablo St., MCH 142, Los Angeles, CA 90033. Phone: (323) 442-1063. Fax: (323) 225-2369. E-mail: stohlman{at}hsc.usc.edu.

Journal of Virology, March 2000, p. 2447-2450, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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