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Journal of Virology, March 2000, p. 2443-2446, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Elevated Serum Transforming Growth Factor beta 1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM

Jingwu Xu,1 Ali Ahmad,1,* James F. Jones,2 Riccardo Dolcetti,3 Emanuela Vaccher,4 Umapati Prasad,5 and José Menezes1,*

Laboratory of Immunovirology, Pediatric Research Center and Department of Microbiology & Immunology, University of Montreal and Sainte-Justine Hospital, Montreal, Quebec, Canada1; Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado2; Division of Experimental Oncology3 and Division of Medical Oncology and AIDS Program,4 Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano (PN), Italy; and Department of Otorhinolaryngology, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia5

Received 3 September 1999/Accepted 9 December 1999

Transforming growth factor beta  (TGF-beta ) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-beta in various EBV-associated diseases correlating positively with EBV-specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

* Corresponding author. Mailing address: Laboratory of Immunovirology, Hôpital Sainte-Justine, 3175 Côte Ste-Catherine, Montreal, Quebec H3T 1C5, Canada. Phone: (514) 345-4691. Fax: (514) 345-4801. E-mail for J. Menezes: svanasve{at}justine.umontreal.ca. E-mail for A. Ahmad: ahmada{at}justine.umontreal.ca.

Journal of Virology, March 2000, p. 2443-2446, Vol. 74, No. 5
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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