Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+ T Cells and Associated with a Proliferative Response to p24 Antigen

doi:10.1128/JVI.74.4.2023-2028.2000

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Journal of Virology, February 2000, p. 2023-2028, Vol. 74, No. 4
0022-538X/00/$04.00+0

Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8⁺ T Cells and Associated with a Proliferative Response to p24 Antigen

Juan Carlos Lopez Bernaldo de Quiros,¹^,² W. Lesley Shupert,² Andrew C. McNeil,² Juan C. Gea-Banacloche,² Mark Flanigan,² Ann Savage,² Lisa Martino,² Emma E. Weiskopf,² Hiromi Imamichi,³ Yi-Ming Zhang,³ Joseph Adelsburger,³ Randy Stevens,³ Philip M. Murphy,⁴ Peter A. Zimmerman,⁴ Claire W. Hallahan,² Richard T. Davey Jr.,² and Mark Connors²^,^*

Servicio de Medicina Interna 1, Clinica Puerta de Hierro, Universidad Autonoma de Madrid, and Servicio de Microbiologia, Hospital General Gregorio Maranon, Madrid, Spain,¹ and Laboratory of Immunoregulation² and Laboratory of Host Defense,⁴ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, and SAIC/Frederick, Frederick Cancer Research and Development Center, Frederick,³ Maryland

Received 11 February 1999/Accepted 10 November 1999

High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted withperipheral blood mononuclear cells of four long-term nonprogressors(LTNPs). Resistance was abrogated by depletion of CD8⁺ T cells in vivo and was observed only in LTNPs with proliferativeresponses to p24. In a subgroup of nonprogressors, CD8⁺ T cells mediated restriction of challenge viruses, and this responsewas associated with strong proliferative responses to p24antigen.

^* Corresponding author. Mailing address: National Institutes of Health, Building 10, Room 11B-09, 10 Center Dr., MSC 1876, Bethesda,MD 20892. Phone: (301) 496-8057. Fax: (301) 402-0070. E-mail:mconnors{at}atlas.niaid.nih.gov.

Journal of Virology, February 2000, p. 2023-2028, Vol. 74, No. 4
0022-538X/00/$04.00+0

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