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Journal of Virology, February 2000, p. 1572-1577, Vol. 74, No. 3
Molecular Virology Group, Department of
Medical Microbiology and Genitourinary Medicine, University of
Liverpool, Liverpool, United Kingdom1;
Department of Human Retrovirology, Academic Medical Center,
University of Amsterdam, Amsterdam, The
Netherlands2; Laboratory of Molecular
Microbiology, National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Bethesda,
Maryland3; and Paul-Ehrlich-Institut,
Langen, Germany4
Received 19 July 1999/Accepted 8 November 1999
Primate gamma-2 herpesviruses (rhadinoviruses) have so far been
found in humans (Kaposi's sarcoma-associated herpesvirus [KSHV], also called human herpesvirus 8), macaques (Macaca spp.)
(rhesus rhadinovirus [RRV] and retroperitoneal fibromatosis
herpesvirus [RFHV]), squirrel monkeys (Saimiri sciureus)
(herpesvirus saimiri), and spider monkeys (Ateles spp.)
(herpesvirus ateles). Using serological screening and degenerate
consensus primer PCR for the viral DNA polymerase gene, we have
detected sequences from two distinct gamma-2 herpesviruses, termed
Chlorocebus rhadinovirus 1 (ChRV1) and ChRV2, in African
green monkeys. ChRV1 is more closely related to KSHV and RFHV, whereas
ChRV2 is closest to RRV. Our findings suggest the existence of two
distinct rhadinovirus lineages, represented by the KSHV/RFHV/ChRV1
group and the RRV/ChRV2 group, respectively, in at least two Old World
monkey species. Antibodies to members of the RRV/ChRV2 lineage may
cross-react in an immunofluorescence assay for early and late KSHV antigens.
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Two Distinct Gamma-2 Herpesviruses in African Green
Monkeys: a Second Gamma-2 Herpesvirus Lineage among Old World
Primates?
*
Corresponding author. Mailing address: Department of
Medical Microbiology and G.U. Medicine, University of Liverpool, Duncan Building, Daulby St., Liverpool L69 3GA, United Kingdom. Phone: 44-151-7064381. Fax: 44-151-7065805. E-mail:
tschulz{at}liv.ac.uk.
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