This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Midgley, R. S.
Right arrow Articles by Lee, S. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Midgley, R. S.
Right arrow Articles by Lee, S. P.

 Previous Article  |  Next Article 

Journal of Virology, February 2000, p. 1544-1548, Vol. 74, No. 3
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Novel Intertypic Recombinants of Epstein-Barr Virus in the Chinese Population

R. S. Midgley,1 N. W. Blake,1 Q. Y. Yao,1 D. Croom-Carter,1 S. T. Cheung,2 S. F. Leung,2 A. T. C. Chan,3 P. J. Johnson,3 D. Huang,2 A. B. Rickinson,1 and S. P. Lee1,*

CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom,1 and Department of Pathology2 and Department of Clinical Oncology,3 The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong

Received 2 July 1999/Accepted 1 November 1999

Among 34 Epstein-Barr virus isolates from nonimmunocompromised Chinese donors, we identified three intertypic recombinants with type 1 sequences at the EBNA2 locus and type 2 sequences at some or all of the EBNA3A, -3B, and -3C loci. These appear to have arisen from independent, evolutionarily recent recombination events; such events may be commoner in nonimmunocompromised populations than hitherto imagined.

* Corresponding author. Mailing address: CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Phone: 44-121-414-4485. Fax: 44-121-414-4486. E-mail: S.P.Lee{at}bham.ac.uk.

Journal of Virology, February 2000, p. 1544-1548, Vol. 74, No. 3
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Norberg, P., Kasubi, M. J., Haarr, L., Bergstrom, T., Liljeqvist, J.-A. (2007). Divergence and Recombination of Clinical Herpes Simplex Virus Type 2 Isolates. J. Virol. 81: 13158-13167 [Abstract] [Full Text]  
  • Norberg, P., Liljeqvist, J.-A., Bergstrom, T., Sammons, S., Schmid, D. S., Loparev, V. N. (2006). Complete-Genome Phylogenetic Approach to Varicella-Zoster Virus Evolution: Genetic Divergence and Evidence for Recombination. J. Virol. 80: 9569-9576 [Abstract] [Full Text]  
  • Peters, G. A., Tyler, S. D., Grose, C., Severini, A., Gray, M. J., Upton, C., Tipples, G. A. (2006). A Full-Genome Phylogenetic Analysis of Varicella-Zoster Virus Reveals a Novel Origin of Replication-Based Genotyping Scheme and Evidence of Recombination between Major Circulating Clades. J. Virol. 80: 9850-9860 [Abstract] [Full Text]  
  • Norberg, P., Bergstrom, T., Rekabdar, E., Lindh, M., Liljeqvist, J.-A. (2004). Phylogenetic Analysis of Clinical Herpes Simplex Virus Type 1 Isolates Identified Three Genetic Groups and Recombinant Viruses. J. Virol. 78: 10755-10764 [Abstract] [Full Text]  
  • Harada, S., Kamata, Y., Ishii, Y., Eda, H., Kitamura, R., Obayashi, M., Ito, S., Ban, F., Kuranari, J., Nakajima, H., Kuze, T., Hayashi, M., Okabe, N., Senpuku, H., Miyasaka, N., Nakamura, Y., Kanegane, H., Yanagi, K. (2004). Maintenance of Serum Immunoglobulin G Antibodies to Epstein-Barr Virus (EBV) Nuclear Antigen 2 in Healthy Individuals from Different Age Groups in a Japanese Population with a High Childhood Incidence of Asymptomatic Primary EBV Infection. CVI 11: 123-130 [Abstract] [Full Text]  
  • Midgley, R. S., Bell, A. I., Yao, Q. Y., Croom-Carter, D., Hislop, A. D., Whitney, B. M., Chan, A. T. C., Johnson, P. J., Rickinson, A. B. (2003). HLA-A11-Restricted Epitope Polymorphism among Epstein-Barr Virus Strains in the Highly HLA-A11-Positive Chinese Population: Incidence and Immunogenicity of Variant Epitope Sequences. J. Virol. 77: 11507-11516 [Abstract] [Full Text]  
  • Midgley, R. S., Bell, A. I., McGeoch, D. J., Rickinson, A. B. (2003). Latent Gene Sequencing Reveals Familial Relationships among Chinese Epstein-Barr Virus Strains and Evidence for Positive Selection of A11 Epitope Changes. J. Virol. 77: 11517-11530 [Abstract] [Full Text]  
  • Fielding, C. A., Sandvej, K., Mehl, A., Brennan, P., Jones, M., Rowe, M. (2001). Epstein-Barr Virus LMP-1 Natural Sequence Variants Differ in Their Potential To Activate Cellular Signaling Pathways. J. Virol. 75: 9129-9141 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»