This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khaiboullina, S. F.
Right arrow Articles by St. Jeor, S. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khaiboullina, S. F.
Right arrow Articles by St. Jeor, S. C.

 Previous Article  |  Next Article 

Journal of Virology, December 2000, p. 11966-11971, Vol. 74, No. 24
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effects of Tumor Necrosis Factor Alpha on Sin Nombre Virus Infection In Vitro

Svetlana F. Khaiboullina,1 Dale M. Netski,1 Peter Krumpe,2 and Stephen C. St. Jeor1,*

Department of Microbiology and Cell and Molecular Biology Program, School of Medicine, University of Nevada---Reno,1 and Veterans Affairs Sierra Nevada Health Care System,2 Reno, Nevada

Received 5 June 2000/Accepted 26 September 2000

Previous data indicate that immune mechanisms may be involved in developing capillary leakage during Sin Nombre virus (SNV) infection. Therefore, we investigated production of tumor necrosis factor alpha (TNF-alpha ) by human alveolar macrophages and human umbilical vein endothelial cells (HUVEC) after infection with SNV. In addition, we examined the effect of TNF-alpha on HUVEC monolayer leakage. Our results reveal that although TNF-alpha decreases accumulation of viral nucleoproteins, TNF-alpha levels do not change in SNV-infected cells. In addition, supernatants from SNV-infected human alveolar macrophages did not cause a significant increase in endothelial monolayer permeability.

* Corresponding author. Mailing address: Department of Microbiology, University of Nevada---Reno, Reno, NV 89557. Phone: (775) 784-4123. Fax: (775) 784-1620. E-mail: stjeor{at}med.unr.edu.

Journal of Virology, December 2000, p. 11966-11971, Vol. 74, No. 24
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Taylor, S. L., Frias-Staheli, N., Garcia-Sastre, A., Schmaljohn, C. S. (2009). Hantaan Virus Nucleocapsid Protein Binds to Importin {alpha} Proteins and Inhibits Tumor Necrosis Factor Alpha-Induced Activation of Nuclear Factor Kappa B. J. Virol. 83: 1271-1279 [Abstract] [Full Text]  
  • Gavrilovskaya, I. N., Gorbunova, E. E., Mackow, N. A., Mackow, E. R. (2008). Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor VEGF, while Angiopoietin 1 and Sphingosine 1-Phosphate Inhibit Hantavirus-Directed Permeability. J. Virol. 82: 5797-5806 [Abstract] [Full Text]  
  • Puro, R., Schneider, R. J. (2007). Tumor Necrosis Factor Activates a Conserved Innate Antiviral Response to Hepatitis B Virus That Destabilizes Nucleocapsids and Reduces Nuclear Viral DNA. J. Virol. 81: 7351-7362 [Abstract] [Full Text]  
  • Klingstrom, J., Hardestam, J., Stoltz, M., Zuber, B., Lundkvist, A., Linder, S., Ahlm, C. (2006). Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin.. J. Virol. 80: 8279-8282 [Abstract] [Full Text]  
  • Asper, M., Sternsdorf, T., Hass, M., Drosten, C., Rhode, A., Schmitz, H., Gunther, S. (2004). Inhibition of Different Lassa Virus Strains by Alpha and Gamma Interferons and Comparison with a Less Pathogenic Arenavirus. J. Virol. 78: 3162-3169 [Abstract] [Full Text]  
  • Kilpatrick, E. D., Terajima, M., Koster, F. T., Catalina, M. D., Cruz, J., Ennis, F. A. (2004). Role of Specific CD8+ T Cells in the Severity of a Fulminant Zoonotic Viral Hemorrhagic Fever, Hantavirus Pulmonary Syndrome. J. Immunol. 172: 3297-3304 [Abstract] [Full Text]  
  • Seo, S. H., Webster, R. G. (2002). Tumor Necrosis Factor Alpha Exerts Powerful Anti-Influenza Virus Effects in Lung Epithelial Cells. J. Virol. 76: 1071-1076 [Abstract] [Full Text]  
  • Sundstrom, J. B., McMullan, L. K., Spiropoulou, C. F., Hooper, W. C., Ansari, A. A., Peters, C. J., Rollin, P. E. (2001). Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells. J. Virol. 75: 6070-6085 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»