Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses

doi:10.1128/JVI.74.24.11825-11831.2000

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Journal of Virology, December 2000, p. 11825-11831, Vol. 74, No. 24
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses

Yasuo Suzuki,¹ Toshihiro Ito,² Takashi Suzuki,¹ Robert E. Holland Jr.,³ Thomas M. Chambers,³ Makoto Kiso,⁴ Hideharu Ishida,⁴ and Yoshihiro Kawaoka⁵^,⁶^,^*

Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka-shi 422-8526,¹ Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680-8553,² Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-1193,⁴ and Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639,⁶ Japan; Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky 40546³; and Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706⁵

Received 3 May 2000/Accepted 14 September 2000

The distribution of sialic acid (SA) species varies among animal species, but the biological role of this variation is largelyunknown. Influenza viruses differ in their ability to recognizeSA-galactose (Gal) linkages, depending on the animal hosts fromwhich they are isolated. For example, human viruses preferentiallyrecognize SA linked to Gal by the $alpha$ 2,6(SA $alpha$ 2,6Gal) linkage, whileequine viruses favor SA $alpha$ 2,3Gal. However, whether a differencein relative abundance of specific SA species (N-acetylneuraminicacid [NeuAc] and N-glycolylneuraminic acid [NeuGc]) among differentanimals affects the replicative potential of influenza virusesis uncertain. We therefore examined the requirement for the hemagglutinin(HA) for support of viral replication in horses, using viruseswhose HAs differ in receptor specificity. A virus with an HA recognizingNeuAc $alpha$ 2,6Gal but not NeuAc $alpha$ 2,3Gal or NeuGc $alpha$ 2,3Gal failed to replicatein horses, while one with an HA recognizing the NeuGc $alpha$ 2,3Gal moietyreplicated in horses. Furthermore, biochemical and immunohistochemicalanalyses and a lectin-binding assay demonstrated the abundanceof the NeuGc $alpha$ 2,3Gal moiety in epithelial cells of horse trachea,indicating that recognition of this moiety is critical for viralreplication in horses. Thus, these results provide evidence ofa biological effect of different SA species in differentanimals.

^* Corresponding author. Mailing address: Department of Pathobiological Sciences, School of Veterinary Medicine, University ofWisconsin-Madison, 2015 Linden Dr. West, Madison, WI 53706. Phone:(608) 265-4925. Fax: (608) 265-5622. E-mail: kawaokay{at}svm.vetmed.wisc.edu.

Journal of Virology, December 2000, p. 11825-11831, Vol. 74, No. 24
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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