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Journal of Virology, December 2000, p. 11422-11425, Vol. 74, No. 23
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

CD4 T-Cell Responses to Herpes Simplex Virus Type 2 Major Capsid Protein VP5: Comparison with Responses to Tegument and Envelope Glycoproteins

David M. Koelle,1,2,3,* Mark Schomogyi,1 Christopher McClurkan,2 Sigrid N. Reymond,3 and Hongbo B. Chen2,3

Departments of Medicine1 and Laboratory Medicine,2 University of Washington, Seattle, Washington 98105, and Fred Hutchinson Cancer Research Center, Seattle, Washington 981093

Received 31 July 2000/Accepted 11 September 2000

We used CD4 lymphocyte clones from herpes simplex virus type 2 (HSV-2) lesions or the cervix and molecular libraries of HSV-2 DNA to define HSV-2 major capsid protein VP5 and glycoprotein E (gE) as T-cell antigens. Responses to eight HSV-2 glycoprotein, tegument, nonstructural, or capsid antigens were compared in 19 donors. Recognition of VP5 and tegument VP22 were similar to that of gB2 and gD2, currently under study as vaccines. These prevalence data suggest that HSV capsid and tegument proteins may also be candidate vaccine antigens.

* Corresponding author. Mailing address: Virology Division, Box 359690, Harborview Medical Center, 325 9th Ave., Seattle, WA 98104-2499. Phone: (206) 341-4207. Fax: (206) 341-5203. E-mail: viralimm{at}u.washington.edu.

Journal of Virology, December 2000, p. 11422-11425, Vol. 74, No. 23
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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Copyright © 2000 by the American Society for Microbiology. All rights reserved.