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Journal of Virology, December 2000, p. 11413-11417, Vol. 74, No. 23
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparison of Viral Genomic RNA Sorting Mechanisms in Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Moloney Murine Leukemia Virus

Nijsje Dorman and Andrew Lever*

University of Cambridge Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom

Received 10 April 2000/Accepted 8 September 2000

Genomic RNA sorting between translation and packaging was examined for human immunodeficiency virus type 1 (HIV-1) and HIV-2 using actinomycin D and leptomycin B treatment. Both viruses behaved differently from a simple retrovirus under actinomycin D treatment. With leptomycin B, the lack of apparent functional separation between translation and packaging functions in lentiviruses was confirmed. HIV-2 RNA levels were more stable, but reverse transcriptase production declined similarly to HIV-1.

* Corresponding author. Mailing address: University of Cambridge Department of Medicine, Level 5, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom. Phone: 44-1223-336747. Fax: 44-1223-336846. E-mail: amll1{at}mole.bio.cam.ac.uk.

Journal of Virology, December 2000, p. 11413-11417, Vol. 74, No. 23
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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