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Journal of Virology, December 2000, p. 11394-11397, Vol. 74, No. 23
0022-538X/00/$04.00+0

Ternary Complex Factors and Cofactors Are Essential for Human T-Cell Leukemia Virus Type 1 Tax Transactivation of the Serum Response Element

Maureen Shuhdagger and David Derse*

Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, Frederick, Maryland 21702-12011

Received 13 June 2000/Accepted 15 September 2000

The human T-cell leukemia virus type 1 Tax protein activates the expression of cellular immediate early genes controlled by the serum response element (SRE), which contains both the serum response factor (SRF) binding element (CArG box) and the ternary complex factor (TCF) binding element (Ets box). We show that TCF binding is necessary for Tax activation of the SRE and that Tax directly interacts with TCFs in vitro. In addition, Tax interactions with CREB binding protein (CBP) and p300- and CBP-associated factor were found to be essential for Tax activation of SRF-mediated transcription.

* Corresponding author. Mailing address: Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, Frederick, MD 21702-1201. Phone: (301) 846-5611. Fax: (301) 846-6863. E-mail: derse{at}mail.ncifcrf.gov.

dagger Present address: Department of Biological Sciences, Loyola University New Orleans, New Orleans, LA 70118.

Journal of Virology, December 2000, p. 11394-11397, Vol. 74, No. 23
0022-538X/00/$04.00+0


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