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Journal of Virology, November 2000, p. 10834-10837, Vol. 74, No. 22
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Porcine Reproductive and Respiratory Syndrome Virus: Description of Persistence in Individual Pigs upon Experimental Infection†

R. Allende,1 W. W. Laegreid,2 G. F. Kutish,3 J. A. Galeota,1 R. W. Wills,1 and F. A. Osorio1,*

Department of Veterinary and Biomedical Sciences, University of Nebraska---Lincoln, Lincoln, Nebraska 68583-09051; U.S. Meat Animal Research Center, U.S. Department of Agriculture/Agricultural Research Service, Clay Center, Nebraska 689332; and Plum Island Animal Disease Center, U.S. Department of Agriculture/ Agricultural Research Service, Greenport, New York 119443

Received 5 May 2000/Accepted 29 August 2000

We studied the persistence of porcine reproductive and respiratory syndrome virus (PRRSV) in individual experimentally infected pigs, during a period of up to 150 days postinfection (dpi). The results of this study suggest that the persistence of PRRSV involves continuous viral replication but that it is not a true steady-state persistent infection. The virus eventually clears the body and seems to do it in most of the animals by 150 dpi or shortly thereafter. High genetic stability was seen for several regions of the persistent PRRSV's genome, although some consistent mutations in the genes of envelope glycoproteins and M protein were also observed.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Sciences, University of Nebraska---Lincoln, Lincoln, NE 68583-0905. Phone: (402) 472-7809. Fax: (402) 472-3094. E-mail: fosorio{at}unl.edu.

dagger This paper is published with the authorization of the Director of the Agricultural Research Division of the University of Nebraska---Lincoln and corresponds to IANR publication no. 13009.

Journal of Virology, November 2000, p. 10834-10837, Vol. 74, No. 22
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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