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Journal of Virology, November 2000, p. 10819-10821, Vol. 74, No. 22
0022-538X/00/$04.00+0

The Genomic RNA in Ty1 Virus-Like Particles Is Dimeric

Ya-Xiong Feng,1 Sharon P. Moore,2 David J. Garfinkel,2 and Alan Rein1,*

HIV Drug Resistance Program1 and Gene Regulation and Chromosome Biology Laboratory,2 National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland

Received 3 April 2000/Accepted 19 August 2000

The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized during the proteolytic maturation of the particle. The stabilization of the dimer suggests that one of the cleavage products of TyA1 possesses nucleic acid chaperone activity.

* Corresponding author. Mailing address: Building 535, Room 211, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702-1201. Phone: (301) 846-1361. Fax: (301) 846-7146. E-mail: rein{at}ncifcrf.gov.

Journal of Virology, November 2000, p. 10819-10821, Vol. 74, No. 22
0022-538X/00/$04.00+0


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