This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Katz, J. M.
Right arrow Articles by Subbarao, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Katz, J. M.
Right arrow Articles by Subbarao, K.

 Previous Article  |  Next Article 

Journal of Virology, November 2000, p. 10807-10810, Vol. 74, No. 22
0022-538X/00/$04.00+0

Molecular Correlates of Influenza A H5N1 Virus Pathogenesis in Mice

Jacqueline M. Katz,* Xiuhua Lu, Terrence M. Tumpey,dagger Catherine B. Smith, Michael W. Shaw, and Kanta Subbarao

Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

Received 12 June 2000/Accepted 23 August 2000

Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 human H5N1 isolates characterized, nine displayed a high-, five a low-, and one an intermediate-pathogenicity phenotype in the BALB/c mouse model. Sequence analysis determined that five specific amino acids in four proteins correlated with pathogenicity in mice. Alone or in combination, these specific residues are the likely determinants of virulence of human H5N1 influenza viruses in this model.


* Corresponding author. Mailing address: Influenza Branch, Mailstop G-16, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333. Phone: (404) 639-3591. Fax: (404) 639-2334. E-mail: JKatz{at}cdc.gov.

dagger Present address: USDA/ARS/Southeast Poultry Research Laboratories, Athens, Ga.


Journal of Virology, November 2000, p. 10807-10810, Vol. 74, No. 22
0022-538X/00/$04.00+0



This article has been cited by other articles:

  • Fornek, J. L., Gillim-Ross, L., Santos, C., Carter, V., Ward, J. M., Cheng, L. I., Proll, S., Katze, M. G., Subbarao, K. (2009). A Single-Amino-Acid Substitution in a Polymerase Protein of an H5N1 Influenza Virus Is Associated with Systemic Infection and Impaired T-Cell Activation in Mice. J. Virol. 83: 11102-11115 [Abstract] [Full Text]  
  • Lycett, S. J., Ward, M. J., Lewis, F. I., Poon, A. F. Y., Kosakovsky Pond, S. L., Brown, A. J. L. (2009). Detection of Mammalian Virulence Determinants in Highly Pathogenic Avian Influenza H5N1 Viruses: Multivariate Analysis of Published Data. J. Virol. 83: 9901-9910 [Abstract] [Full Text]  
  • Szretter, K. J., Gangappa, S., Belser, J. A., Zeng, H., Chen, H., Matsuoka, Y., Sambhara, S., Swayne, D. E., Tumpey, T. M., Katz, J. M. (2009). Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice. J. Virol. 83: 5825-5834 [Abstract] [Full Text]  
  • Le, Q. M., Sakai-Tagawa, Y., Ozawa, M., Ito, M., Kawaoka, Y. (2009). Selection of H5N1 Influenza Virus PB2 during Replication in Humans. J. Virol. 83: 5278-5281 [Abstract] [Full Text]  
  • Van Hoeven, N., Belser, J. A., Szretter, K. J., Zeng, H., Staeheli, P., Swayne, D. E., Katz, J. M., Tumpey, T. M. (2009). Pathogenesis of 1918 Pandemic and H5N1 Influenza Virus Infections in a Guinea Pig Model: Antiviral Potential of Exogenous Alpha Interferon To Reduce Virus Shedding. J. Virol. 83: 2851-2861 [Abstract] [Full Text]  
  • Mukhtar, M. M., Rasool, S. T., Song, D., Zhu, C., Hao, Q., Zhu, Y., Wu, J. (2007). Origin of highly pathogenic H5N1 avian influenza virus in China and genetic characterization of donor and recipient viruses. J. Gen. Virol. 88: 3094-3099 [Abstract] [Full Text]  
  • Peiris, J. S. M., de Jong, M. D., Guan, Y. (2007). Avian Influenza Virus (H5N1): a Threat to Human Health. Clin. Microbiol. Rev. 20: 243-267 [Abstract] [Full Text]  
  • Szretter, K. J., Gangappa, S., Lu, X., Smith, C., Shieh, W.-J., Zaki, S. R., Sambhara, S., Tumpey, T. M., Katz, J. M. (2007). Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice. J. Virol. 81: 2736-2744 [Abstract] [Full Text]  
  • Cauthen, A. N., Swayne, D. E., Sekellick, M. J., Marcus, P. I., Suarez, D. L. (2007). Amelioration of Influenza Virus Pathogenesis in Chickens Attributed to the Enhanced Interferon-Inducing Capacity of a Virus with a Truncated NS1 Gene. J. Virol. 81: 1838-1847 [Abstract] [Full Text]  
  • Shinya, K., Watanabe, S., Ito, T., Kasai, N., Kawaoka, Y. (2007). Adaptation of an H7N7 equine influenza A virus in mice. J. Gen. Virol. 88: 547-553 [Abstract] [Full Text]  
  • Zhou, J.-Y., Shen, H.-G., Chen, H.-X., Tong, G.-Z., Liao, M., Yang, H.-C., Liu, J.-X. (2006). Characterization of a highly pathogenic H5N1 influenza virus derived from bar-headed geese in China. J. Gen. Virol. 87: 1823-1833 [Abstract] [Full Text]  
  • Chen, H., Li, Y., Li, Z., Shi, J., Shinya, K., Deng, G., Qi, Q., Tian, G., Fan, S., Zhao, H., Sun, Y., Kawaoka, Y. (2006). Properties and Dissemination of H5N1 Viruses Isolated during an Influenza Outbreak in Migratory Waterfowl in Western China.. J. Virol. 80: 5976-5983 [Abstract] [Full Text]  
  • Campitelli, L., Ciccozzi, M., Salemi, M., Taglia, F., Boros, S., Donatelli, I., Rezza, G. (2006). H5N1 influenza virus evolution: a comparison of different epidemics in birds and humans (1997-2004).. J. Gen. Virol. 87: 955-960 [Abstract] [Full Text]  
  • Maines, T. R., Lu, X. H., Erb, S. M., Edwards, L., Guarner, J., Greer, P. W., Nguyen, D. C., Szretter, K. J., Chen, L.-M., Thawatsupha, P., Chittaganpitch, M., Waicharoen, S., Nguyen, D. T., Nguyen, T., Nguyen, H. H. T., Kim, J.-H., Hoang, L. T., Kang, C., Phuong, L. S., Lim, W., Zaki, S., Donis, R. O., Cox, N. J., Katz, J. M., Tumpey, T. M. (2005). Avian Influenza (H5N1) Viruses Isolated from Humans in Asia in 2004 Exhibit Increased Virulence in Mammals. J. Virol. 79: 11788-11800 [Abstract] [Full Text]  
  • Li, Z., Chen, H., Jiao, P., Deng, G., Tian, G., Li, Y., Hoffmann, E., Webster, R. G., Matsuoka, Y., Yu, K. (2005). Molecular Basis of Replication of Duck H5N1 Influenza Viruses in a Mammalian Mouse Model. J. Virol. 79: 12058-12064 [Abstract] [Full Text]  
  • Shinya, K., Hatta, M., Yamada, S., Takada, A., Watanabe, S., Halfmann, P., Horimoto, T., Neumann, G., Kim, J. H., Lim, W., Guan, Y., Peiris, M., Kiso, M., Suzuki, T., Suzuki, Y., Kawaoka, Y. (2005). Characterization of a Human H5N1 Influenza A Virus Isolated in 2003. J. Virol. 79: 9926-9932 [Abstract] [Full Text]  
  • Nguyen, D. C., Uyeki, T. M., Jadhao, S., Maines, T., Shaw, M., Matsuoka, Y., Smith, C., Rowe, T., Lu, X., Hall, H., Xu, X., Balish, A., Klimov, A., Tumpey, T. M., Swayne, D. E., Huynh, L. P. T., Nghiem, H. K., Nguyen, H. H. T., Hoang, L. T., Cox, N. J., Katz, J. M. (2005). Isolation and Characterization of Avian Influenza Viruses, Including Highly Pathogenic H5N1, from Poultry in Live Bird Markets in Hanoi, Vietnam, in 2001. J. Virol. 79: 4201-4212 [Abstract] [Full Text]  
  • Lee, C.-W., Suarez, D. L., Tumpey, T. M., Sung, H.-W., Kwon, Y.-K., Lee, Y.-J., Choi, J.-G., Joh, S.-J., Kim, M.-C., Lee, E.-K., Park, J.-M., Lu, X., Katz, J. M., Spackman, E., Swayne, D. E., Kim, J.-H. (2005). Characterization of Highly Pathogenic H5N1 Avian Influenza A Viruses Isolated from South Korea. J. Virol. 79: 3692-3702 [Abstract] [Full Text]  
  • Govorkova, E. A., Rehg, J. E., Krauss, S., Yen, H.-L., Guan, Y., Peiris, M., Nguyen, T. D., Hanh, T. H., Puthavathana, P., Long, H. T., Buranathai, C., Lim, W., Webster, R. G., Hoffmann, E. (2005). Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004. J. Virol. 79: 2191-2198 [Abstract] [Full Text]  
  • Lipatov, A. S., Govorkova, E. A., Webby, R. J., Ozaki, H., Peiris, M., Guan, Y., Poon, L., Webster, R. G. (2004). Influenza: Emergence and Control. J. Virol. 78: 8951-8959 [Full Text]  
  • Chen, H., Deng, G., Li, Z., Tian, G., Li, Y., Jiao, P., Zhang, L., Liu, Z., Webster, R. G., Yu, K. (2004). The evolution of H5N1 influenza viruses in ducks in southern China. Proc. Natl. Acad. Sci. USA 101: 10452-10457 [Abstract] [Full Text]  
  • Tompkins, S. M., Lo, C.-Y., Tumpey, T. M., Epstein, S. L. (2004). Protection against lethal influenza virus challenge by RNA interference in vivo. Proc. Natl. Acad. Sci. USA 101: 8682-8686 [Abstract] [Full Text]  
  • Lipatov, A. S., Krauss, S., Guan, Y., Peiris, M., Rehg, J. E., Perez, D. R., Webster, R. G. (2003). Neurovirulence in Mice of H5N1 Influenza Virus Genotypes Isolated from Hong Kong Poultry in 2001. J. Virol. 77: 3816-3823 [Abstract] [Full Text]  
  • Reid, A. H., Fanning, T. G., Janczewski, T. A., McCall, S., Taubenberger, J. K. (2002). Characterization of the 1918 "Spanish" Influenza Virus Matrix Gene Segment. J. Virol. 76: 10717-10723 [Abstract] [Full Text]  
  • Tumpey, T. M., Suarez, D. L., Perkins, L. E. L., Senne, D. A., Lee, J.-g., Lee, Y.-J., Mo, I.-P., Sung, H.-W., Swayne, D. E. (2002). Characterization of a Highly Pathogenic H5N1 Avian Influenza A Virus Isolated from Duck Meat. J. Virol. 76: 6344-6355 [Abstract] [Full Text]  
  • Zitzow, L. A., Rowe, T., Morken, T., Shieh, W.-J., Zaki, S., Katz, J. M. (2002). Pathogenesis of Avian Influenza A (H5N1) Viruses in Ferrets. J. Virol. 76: 4420-4429 [Abstract] [Full Text]  
  • Hatta, M., Gao, P., Halfmann, P., Kawaoka, Y. (2001). Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses. Science 293: 1840-1842 [Abstract] [Full Text]  
  • Yao, Y., Mingay, L. J., McCauley, J. W., Barclay, W. S. (2001). Sequences in Influenza A Virus PB2 Protein That Determine Productive Infection for an Avian Influenza Virus in Mouse and Human Cell Lines. J. Virol. 75: 5410-5415 [Abstract] [Full Text]