Molecular Correlates of Influenza A H5N1 Virus Pathogenesis in Mice

doi:10.1128/JVI.74.22.10807-10810.2000

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Journal of Virology, November 2000, p. 10807-10810, Vol. 74, No. 22
0022-538X/00/$04.00+0

Molecular Correlates of Influenza A H5N1 Virus Pathogenesis in Mice

Jacqueline M. Katz,^* Xiuhua Lu, Terrence M. Tumpey, Catherine B. Smith, Michael W. Shaw, and Kanta Subbarao

Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

Received 12 June 2000/Accepted 23 August 2000

Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 humanH5N1 isolates characterized, nine displayed a high-, five a low-,and one an intermediate-pathogenicity phenotype in the BALB/cmouse model. Sequence analysis determined that five specific aminoacids in four proteins correlated with pathogenicity in mice.Alone or in combination, these specific residues are the likelydeterminants of virulence of human H5N1 influenza viruses in thismodel.

^* Corresponding author. Mailing address: Influenza Branch, Mailstop G-16, Centers for Disease Control and Prevention, 1600 CliftonRoad, Atlanta, GA 30333. Phone: (404) 639-3591. Fax: (404) 639-2334.E-mail: JKatz{at}cdc.gov.

Present address: USDA/ARS/Southeast Poultry Research Laboratories, Athens,Ga.

Journal of Virology, November 2000, p. 10807-10810, Vol. 74, No. 22
0022-538X/00/$04.00+0

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