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Journal of Virology, November 2000, p. 10256-10259, Vol. 74, No. 21
HIV and Retrovirology
Branch1 and
Tuberculosis/Mycobacteriology Branch,2
Division of AIDS, STD, and TB Laboratory Research, Centers for
Disease Control and Prevention, Public Health Service, U.S.
Department of Health and Human Services, Atlanta, Georgia
Received 22 May 2000/Accepted 14 August 2000
Human immunodeficiency virus type 1 (HIV-1) bearing HLA-DR in its
envelope was detected in plasma from all patients with chronic HIV-1
infection (n = 16) and was present at higher levels in
patients with active tuberculosis coinfection (n = 6).
Intriguingly, however, HLA-DR was not detectable in HIV-1 from patients
during primary viremia (n = 6), suggesting the
possibility of virus replication in less-activated cells.
0022-538X/00/$04.00+0
Incorporation of HLA-DR into the Envelope of Human
Immunodeficiency Virus Type 1 In Vivo: Correlation with Stage of
Disease and Presence of Opportunistic Infection
*
Corresponding author. Mailing address: Mail-Stop G19,
HIV and Retrovirology Branch, Centers for Disease Control and
Prevention, 1600 Clifton Rd., NE, Atlanta, GA 30333. Phone: (404)
639-1033. Fax: (404) 639-1174. E-mail: stb3{at}cdc.gov.
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