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Journal of Virology, November 2000, p. 10240-10244, Vol. 74, No. 21
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

HLA Class I-Restricted Cytotoxic T-Cell Epitopes of the Respiratory Syncytial Virus Fusion Protein

A. H. Brandenburg,1,dagger L. de Waal,1 H. H. Timmerman,1 P. Hoogerhout,2 R. L. de Swart,1 and A. D. M. E. Osterhaus1,*

Institute of Virology, Erasmus University Hospital, 3000 DR Rotterdam,1 and Laboratory for Bacterial Vaccine Research, National Institute of Public Health and the Environment, 3720 BA Bilthoven,2 The Netherlands

Received 30 May 2000/Accepted 1 August 2000

Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.

* Corresponding author. Mailing address: Institute of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. Phone: 31-10-4088066. Fax: 31-10-4089485. E-mail: osterhaus{at}viro.fgg.eur.nl.

dagger Present address: LVF, 8917 EN Leeuwarden, The Netherlands.

Journal of Virology, November 2000, p. 10240-10244, Vol. 74, No. 21
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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