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Journal of Virology, November 2000, p. 10240-10244, Vol. 74, No. 21
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
HLA Class I-Restricted Cytotoxic T-Cell Epitopes of
the Respiratory Syncytial Virus Fusion Protein
A. H.
Brandenburg,1,
L.
de
Waal,1
H. H.
Timmerman,1
P.
Hoogerhout,2
R. L.
de Swart,1 and
A. D. M. E.
Osterhaus1,*
Institute of Virology, Erasmus University
Hospital, 3000 DR Rotterdam,1 and
Laboratory for Bacterial Vaccine Research, National Institute
of Public Health and the Environment, 3720 BA
Bilthoven,2 The Netherlands
Received 30 May 2000/Accepted 1 August 2000
Virus-specific cytotoxic T lymphocytes (CTL) play a major role in
the clearance of respiratory syncytial virus (RSV) infection. We have
generated cytotoxic T-cell clones (TCC) from two infants who had just
recovered from severe RSV infection. These TCC were functionally
characterized and used to identify HLA class I (B57 and C12)-restricted
CTL epitopes of RSV.
*
Corresponding author. Mailing address: Institute of
Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR
Rotterdam, The Netherlands. Phone: 31-10-4088066. Fax: 31-10-4089485. E-mail: osterhaus{at}viro.fgg.eur.nl.

Present address: LVF, 8917 EN Leeuwarden, The
Netherlands.
Journal of Virology, November 2000, p. 10240-10244, Vol. 74, No. 21
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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