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Journal of Virology, November 2000, p. 10236-10239, Vol. 74, No. 21
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Sequestration of TT Virus of Restricted Genotypes in Peripheral Blood Mononuclear Cells

Hiroaki Okamoto,1 Masaharu Takahashi,1 Naomi Kato,2 Masako Fukuda,3 Akio Tawara,4 Satoko Fukuda,5 Takeshi Tanaka,2 Yuzo Miyakawa,6 and Makoto Mayumi1

Immunology Division and Division of Molecular Virology, Jichi Medical School, Tochigi-Ken 329-0498,1 Japanese Red Cross Saitama Blood Center, Saitama-Ken 338-0001,2 Institute of Immunology, Tokyo 112-0004,3 First Department of Internal Medicine, Yamanashi Medical University, Yamanashi-Ken 409-3898,4 Japanese Red Cross Tochigi Blood Center, Tochigi-Ken 321-0166,5 and Miyakawa Memorial Research Foundation, Tokyo 107-0062,6 Japan

Received 18 April 2000/Accepted 3 August 2000

Peripheral blood mononuclear cells (PBMC) harbored TT virus (TTV) of genotypes (3 and 4) different from those (1 and 2) of free virions in plasma of the same individuals. PBMC may act as a reservoir, and TTV of particular genotypes might have tropism for hematopoietic cells.

Journal of Virology, November 2000, p. 10236-10239, Vol. 74, No. 21
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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