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Journal of Virology, October 2000, p. 9762-9765, Vol. 74, No. 20
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Diminished Primary and Secondary Influenza Virus-Specific CD8+ T-Cell Responses in CD4-Depleted Igminus /minus Mice

Janice M. Riberdy,1 Jan P. Christensen,2 Kristen Branum,1 and Peter C. Doherty1,*

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105,1 and Institute of Medical Microbiology and Immunology, The Panum Institute, Copenhagen, Denmark2

Received 3 May 2000/Accepted 26 July 2000

Optimal expansion of influenza virus nucleoprotein (DbNP366)-specific CD8+ T cells following respiratory challenge of naive Ig-/- µMT mice was found to require CD4+ T-cell help, and this effect was also observed in primed animals. Absence of the CD4+ population was consistently correlated with diminished recruitment of virus-specific CD8+ T cells to the infected lung, delayed virus clearance, and increased morbidity. The splenic CD8+ set generated during the recall response in Ig-/- mice primed at least 6 months previously showed a normal profile of gamma interferon production subsequent to short-term, in vitro stimulation with viral peptide, irrespective of a concurrent CD4+ T-cell response. Both the magnitude and the localization profiles of virus-specific CD8+ T cells, though perhaps not their functional characteristics, are thus modified in mice lacking CD4+ T cells.

* Corresponding author. Mailing address: Department of Immunology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105. Phone: (901) 495-3470. Fax: (901) 495-3107. E-mail: peter.doherty{at}stjude.org.

Journal of Virology, October 2000, p. 9762-9765, Vol. 74, No. 20
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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