Histone Acetylation and Reactivation of Epstein-Barr Virus from Latency

doi:10.1128/JVI.74.2.710-720.2000

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Journal of Virology, January 2000, p. 710-720, Vol. 74, No. 2
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Histone Acetylation and Reactivation of Epstein-Barr Virus from Latency

Peter J. Jenkins,¹ Ulrich K. Binné,¹ and Paul J. Farrell¹^,²^,^*

Ludwig Institute for Cancer Research¹ and Virology and Cell Biology Section,² Imperial College School of Medicine, St. Mary's Campus, London W2 1PG, United Kingdom

Received 22 June 1999/Accepted 7 October 1999

Induction of the viral BZLF1 gene has previously been shown to be one of the first steps in the reactivation of Epstein-Barrvirus (EBV). Using an EBV oriP episomal vector system, we havereconstituted the regulation of the promoter for BZLF1 on stablytransfected episomes, mapped promoter elements required for thatregulation, and investigated mechanisms that may control the switchbetween latency and the lytic cycle. Changes in histone acetylationat the promoter for the BZLF1 gene appear to be a key part ofthe reactivation mechanism of thisherpesvirus.

^* Corresponding author. Mailing address: Ludwig Institute for Cancer Research, Imperial College School of Medicine, St. Mary'sCampus, Norfolk Pl., London W2 1PG, United Kingdom. Phone: 44-171-724-5522.Fax: 44-171-724-8586. E-mail: p.farrell{at}ic.ac.uk.

Journal of Virology, January 2000, p. 710-720, Vol. 74, No. 2
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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