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Journal of Virology, January 2000, p. 1029-1032, Vol. 74, No. 2
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Granzyme A, a Noncytolytic Component of CD8+ Cell Granules, Restricts the Spread of Herpes Simplex Virus in the Peripheral Nervous Systems of Experimentally Infected Mice

Rosemarie A. Pereira,1,* Markus M. Simon,2 and Anthony Simmons1

Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia,1 and Max Planck Institute for Immunobiology, D-79108 Freiburg, Germany2

Received 11 August 1999/Accepted 7 October 1999

Control of ganglionic herpes simplex virus (HSV) infection depends on CD8+ cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8+ cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown. Here, it is shown that granzyme A restricts the interneuronal spread of HSV and significantly influences ganglionic virus load.

* Corresponding author. Mailing address: Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia. Phone: 61 8 82223434. Fax: 61 8 82223543. E-mail: Rosemary.Pereira{at}imvs.sa.gov.au.

Journal of Virology, January 2000, p. 1029-1032, Vol. 74, No. 2
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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