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Journal of Virology, September 2000, p. 8740-8743, Vol. 74, No. 18
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Detection and Quantification of CD4+ T Cells with Specificity for a New Major Histocompatibility Complex Class II-Restricted Influenza A Virus Matrix Protein Epitope in Peripheral Blood of Influenza Patients

Thomas Linnemann,1 Günther Jung,2 and Peter Walden1,*

Department of Dermatology and Allergy, Charité, Medical School of the Humboldt University, D-10089 Berlin,1 and Department of Organic Chemistry, University of Tübingen, D-72074 Tübingen,2 Germany

Received 1 March 2000/Accepted 19 June 2000

FVFTLTVPS was identified as the core sequence of a new major histocompatibility complex class II-restricted T-cell epitope of influenza virus matrix protein. Epitope-specific CD4+ T cells were detected in the peripheral blood of patients with frequencies of up to 0.94%, depending on the number of additional terminal amino acids.

* Corresponding author. Mailing address: Department of Dermatology, Charité, Medical Faculty of the Humboldt University, Schumannstr. 20/21, D-10117 Berlin, Germany. Phone: 49-30-2802-4306. Fax: 49-30-2802-8767. E-mail: peter.walden{at}charite.de.

Journal of Virology, September 2000, p. 8740-8743, Vol. 74, No. 18
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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