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Journal of Virology, September 2000, p. 8726-8731, Vol. 74, No. 18
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Coinfection of SCID-hu Thy/Liv Mice with Human Herpesvirus 6 and Human Immunodeficiency Virus Type 1

Alberto Gobbi,1,dagger Cheryl A. Stoddart,2 Giuseppe Locatelli,1 Fabio Santoro,1 Christopher Bare,2 Valerie Linquist-Stepps,2 Mary E. Moreno,2 Nancy W. Abbey,3 Brian G. Herndier,3 Mauro S. Malnati,1 Joseph M. McCune,2,4 and Paolo Lusso1,5,*

Unit of Human Virology, Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy1; Gladstone Institute of Virology and Immunology,2 Department of Pathology,3 and Departments of Medicine and Microbiology and Immunology,4 University of California, San Francisco, California 94110-9100; and Division of Infectious Diseases, University of Bologna, 40138 Bologna, Italy5

Received 22 February 2000/Accepted 9 June 2000

Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.

* Corresponding author. Mailing address: Unit of Human Virology, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy. Phone: 39-02-2643-2821. Fax: 39-02-2643-4905. E-mail: Paolo.Lusso{at}hsr.it.

dagger Present address: Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

Journal of Virology, September 2000, p. 8726-8731, Vol. 74, No. 18
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • De Bolle, L., Naesens, L., De Clercq, E. (2005). Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy. Clin. Microbiol. Rev. 18: 217-245 [Abstract] [Full Text]  
  • Grivel, J.-C., Santoro, F., Chen, S., Faga, G., Malnati, M. S., Ito, Y., Margolis, L., Lusso, P. (2003). Pathogenic Effects of Human Herpesvirus 6 in Human Lymphoid Tissue Ex Vivo. J. Virol. 77: 8280-8289 [Abstract] [Full Text]  
  • Dockrell, D.H. (2003). Human herpesvirus 6: molecular biology and clinical features. J Med Microbiol 52: 5-18 [Abstract] [Full Text]  
  • Locatelli, G., Santoro, F., Veglia, F., Gobbi, A., Lusso, P., Malnati, M. S. (2000). Real-Time Quantitative PCR for Human Herpesvirus 6 DNA. J. Clin. Microbiol. 38: 4042-4048 [Abstract] [Full Text]  


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